Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis

Primary resistance to tyrosine-kinase inhibitors (TKIs) is quite uncommon in chronic-phase Chronic Myeloid Leukemia (CML) and related to still poorly understood mechanisms, as ABL mutations are rarely detected in primary resistant patients. We report the challenging case of a CML patient who was res...

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Autores principales: Orlandi, Ester M., Elena, Chiara, Zibellini, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528049/
https://www.ncbi.nlm.nih.gov/pubmed/26266095
http://dx.doi.org/10.1016/j.lrr.2015.05.003
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author Orlandi, Ester M.
Elena, Chiara
Zibellini, Silvia
author_facet Orlandi, Ester M.
Elena, Chiara
Zibellini, Silvia
author_sort Orlandi, Ester M.
collection PubMed
description Primary resistance to tyrosine-kinase inhibitors (TKIs) is quite uncommon in chronic-phase Chronic Myeloid Leukemia (CML) and related to still poorly understood mechanisms, as ABL mutations are rarely detected in primary resistant patients. We report the challenging case of a CML patient who was resistant to multiple TKIs because of different emerging ABL mutations and became pregnant while on Nilotinib therapy despite repeated and clear discouragement to conceive. She decided to continue with her pregnancy, showing an admirable and incredible perseverance in the pursuit of her personal aims.
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spelling pubmed-45280492015-08-11 Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis Orlandi, Ester M. Elena, Chiara Zibellini, Silvia Leuk Res Rep Case Report Primary resistance to tyrosine-kinase inhibitors (TKIs) is quite uncommon in chronic-phase Chronic Myeloid Leukemia (CML) and related to still poorly understood mechanisms, as ABL mutations are rarely detected in primary resistant patients. We report the challenging case of a CML patient who was resistant to multiple TKIs because of different emerging ABL mutations and became pregnant while on Nilotinib therapy despite repeated and clear discouragement to conceive. She decided to continue with her pregnancy, showing an admirable and incredible perseverance in the pursuit of her personal aims. Elsevier 2015-07-17 /pmc/articles/PMC4528049/ /pubmed/26266095 http://dx.doi.org/10.1016/j.lrr.2015.05.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Orlandi, Ester M.
Elena, Chiara
Zibellini, Silvia
Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
title Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
title_full Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
title_fullStr Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
title_full_unstemmed Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
title_short Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis
title_sort chronic-phase chronic myeloid leukemia: not always a reassuring diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528049/
https://www.ncbi.nlm.nih.gov/pubmed/26266095
http://dx.doi.org/10.1016/j.lrr.2015.05.003
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