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Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor

The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals. In humans, they comprise three prolyl hydroxylases (PHD1–3 or EGLN1–3) and factor inhibiting HIF (FIH). FIH is an asparaginyl hydroxylase catalyzing post-translational modification of HIF-α, resulting in reduction o...

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Detalles Bibliográficos
Autores principales:	Tarhonskaya, Hanna, Hardy, Adam P., Howe, Emily A., Loik, Nikita D., Kramer, Holger B., McCullagh, James S. O., Schofield, Christopher J., Flashman, Emily
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528135/ https://www.ncbi.nlm.nih.gov/pubmed/26112411 http://dx.doi.org/10.1074/jbc.M115.653014

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