A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS

The trimeric envelope spike of HIV-1 mediates virus entry into human cells. The exposed part of the trimer, gp140, consists of two noncovalently associated subunits, gp120 and gp41 ectodomain. A recombinant vaccine that mimics the native trimer might elicit entry-blocking antibodies and prevent viru...

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Detalles Bibliográficos
Autores principales: AlSalmi, Wadad, Mahalingam, Marthandan, Ananthaswamy, Neeti, Hamlin, Christopher, Flores, Dalia, Gao, Guofen, Rao, Venigalla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528139/
https://www.ncbi.nlm.nih.gov/pubmed/26088135
http://dx.doi.org/10.1074/jbc.M115.656611

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