A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

Metabolic adaptation is considered an emerging hallmark of cancer, whereby cancer cells exhibit high rates of glucose consumption with consequent lactate production. To ensure rapid efflux of lactate, most cancer cells express high levels of monocarboxylate transporters (MCTs), which therefore may c...

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Detalles Bibliográficos
Autores principales: Pertega‐Gomes, Nelma, Felisbino, Sergio, Massie, Charlie E, Vizcaino, Jose R, Coelho, Ricardo, Sandi, Chiranjeevi, Simoes‐Sousa, Susana, Jurmeister, Sarah, Ramos‐Montoya, Antonio, Asim, Mohammad, Tran, Maxine, Oliveira, Elsa, Lobo da Cunha, Alexandre, Maximo, Valdemar, Baltazar, Fatima, Neal, David E, Fryer, Lee GD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528232/
https://www.ncbi.nlm.nih.gov/pubmed/25875424
http://dx.doi.org/10.1002/path.4547

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