The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity

Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also p...

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Autores principales: Wallner, Stephanie, Peters, Sebastian, Pitzer, Claudia, Resch, Herbert, Bogdahn, Ulrich, Schneider, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528279/
https://www.ncbi.nlm.nih.gov/pubmed/26301221
http://dx.doi.org/10.3389/fcell.2015.00048
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author Wallner, Stephanie
Peters, Sebastian
Pitzer, Claudia
Resch, Herbert
Bogdahn, Ulrich
Schneider, Armin
author_facet Wallner, Stephanie
Peters, Sebastian
Pitzer, Claudia
Resch, Herbert
Bogdahn, Ulrich
Schneider, Armin
author_sort Wallner, Stephanie
collection PubMed
description Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.
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spelling pubmed-45282792015-08-21 The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity Wallner, Stephanie Peters, Sebastian Pitzer, Claudia Resch, Herbert Bogdahn, Ulrich Schneider, Armin Front Cell Dev Biol Cell and Developmental Biology Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor. Frontiers Media S.A. 2015-08-07 /pmc/articles/PMC4528279/ /pubmed/26301221 http://dx.doi.org/10.3389/fcell.2015.00048 Text en Copyright © 2015 Wallner, Peters, Pitzer, Resch, Bogdahn and Schneider. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wallner, Stephanie
Peters, Sebastian
Pitzer, Claudia
Resch, Herbert
Bogdahn, Ulrich
Schneider, Armin
The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
title The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
title_full The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
title_fullStr The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
title_full_unstemmed The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
title_short The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
title_sort granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528279/
https://www.ncbi.nlm.nih.gov/pubmed/26301221
http://dx.doi.org/10.3389/fcell.2015.00048
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