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Inferring processes underlying B-cell repertoire diversity

We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first after its in...

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Detalles Bibliográficos
Autores principales:	Elhanati, Yuval, Sethna, Zachary, Marcou, Quentin, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528420/ https://www.ncbi.nlm.nih.gov/pubmed/26194757 http://dx.doi.org/10.1098/rstb.2014.0243

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