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Quantifying evolutionary constraints on B-cell affinity maturation

The antibody repertoire of each individual is continuously updated by the evolutionary process of B-cell receptor (BCR) mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput sequencing. Here, we develop modern statistical...

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Detalles Bibliográficos
Autores principales:	McCoy, Connor O., Bedford, Trevor, Minin, Vladimir N., Bradley, Philip, Robins, Harlan, Matsen, Frederick A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528421/ https://www.ncbi.nlm.nih.gov/pubmed/26194758 http://dx.doi.org/10.1098/rstb.2014.0244

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