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Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance
It is often assumed that an animal's metabolic rate can be estimated through measuring the whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely to be a sufficient marker of energy metabolism in many situations. This is due to the inherent variability in the link...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528520/ https://www.ncbi.nlm.nih.gov/pubmed/26203001 http://dx.doi.org/10.1098/rspb.2015.1028 |
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author | Salin, Karine Auer, Sonya K. Rey, Benjamin Selman, Colin Metcalfe, Neil B. |
author_facet | Salin, Karine Auer, Sonya K. Rey, Benjamin Selman, Colin Metcalfe, Neil B. |
author_sort | Salin, Karine |
collection | PubMed |
description | It is often assumed that an animal's metabolic rate can be estimated through measuring the whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely to be a sufficient marker of energy metabolism in many situations. This is due to the inherent variability in the link between oxidation and phosphorylation; that is, the amount of adenosine triphosphate (ATP) generated per molecule of oxygen consumed by mitochondria (P/O ratio). In this article, we describe how the P/O ratio can vary within and among individuals, and in response to a number of environmental parameters, including diet and temperature. As the P/O ratio affects the efficiency of cellular energy production, its variability may have significant consequences for animal performance, such as growth rate and reproductive output. We explore the adaptive significance of such variability and hypothesize that while a reduction in the P/O ratio is energetically costly, it may be associated with advantages in terms of somatic maintenance through reduced production of reactive oxygen species. Finally, we discuss how considering variation in mitochondrial efficiency, together with whole-organism oxygen consumption, can permit a better understanding of the relationship between energy metabolism and life history for studies in evolutionary ecology. |
format | Online Article Text |
id | pubmed-4528520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-45285202015-09-23 Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance Salin, Karine Auer, Sonya K. Rey, Benjamin Selman, Colin Metcalfe, Neil B. Proc Biol Sci Review Articles It is often assumed that an animal's metabolic rate can be estimated through measuring the whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely to be a sufficient marker of energy metabolism in many situations. This is due to the inherent variability in the link between oxidation and phosphorylation; that is, the amount of adenosine triphosphate (ATP) generated per molecule of oxygen consumed by mitochondria (P/O ratio). In this article, we describe how the P/O ratio can vary within and among individuals, and in response to a number of environmental parameters, including diet and temperature. As the P/O ratio affects the efficiency of cellular energy production, its variability may have significant consequences for animal performance, such as growth rate and reproductive output. We explore the adaptive significance of such variability and hypothesize that while a reduction in the P/O ratio is energetically costly, it may be associated with advantages in terms of somatic maintenance through reduced production of reactive oxygen species. Finally, we discuss how considering variation in mitochondrial efficiency, together with whole-organism oxygen consumption, can permit a better understanding of the relationship between energy metabolism and life history for studies in evolutionary ecology. The Royal Society 2015-08-07 /pmc/articles/PMC4528520/ /pubmed/26203001 http://dx.doi.org/10.1098/rspb.2015.1028 Text en © 2015 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Articles Salin, Karine Auer, Sonya K. Rey, Benjamin Selman, Colin Metcalfe, Neil B. Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance |
title | Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance |
title_full | Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance |
title_fullStr | Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance |
title_full_unstemmed | Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance |
title_short | Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance |
title_sort | variation in the link between oxygen consumption and atp production, and its relevance for animal performance |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528520/ https://www.ncbi.nlm.nih.gov/pubmed/26203001 http://dx.doi.org/10.1098/rspb.2015.1028 |
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