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Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong

BACKGROUND: Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV infection in HIV-positive MSM in Hong Kong using a molecular approach. FINDINGS:...

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Autores principales: Chan, Denise P., Lin, Ada W., Wong, Ka Hing, Wong, Ngai Sze, Lee, Shui Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528697/
https://www.ncbi.nlm.nih.gov/pubmed/26253209
http://dx.doi.org/10.1186/s12985-015-0355-8
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author Chan, Denise P.
Lin, Ada W.
Wong, Ka Hing
Wong, Ngai Sze
Lee, Shui Shan
author_facet Chan, Denise P.
Lin, Ada W.
Wong, Ka Hing
Wong, Ngai Sze
Lee, Shui Shan
author_sort Chan, Denise P.
collection PubMed
description BACKGROUND: Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV infection in HIV-positive MSM in Hong Kong using a molecular approach. FINDINGS: We retrospectively examined 24 HIV-positive MSM with acute HCV infection diagnosed between 2009 and 2014 in Hong Kong. Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients. Genotype 3a was the most prevalent as identified in 14 (63.6 %) MSM, followed by 1a in 4 (18.2 %), 6a in 2 (9.1 %), and 1each (4.5 %) for 1b and 2a. The high prevalence of genotype 3a in MSM was in stark contrast to its rarity among HCV infected injection drug users (IDU) in Hong Kong. Phylogenetic analyses revealed a monophyletic HCV-3a cluster composing of MSM without injection history, and a homologous pair with HCV-6a genotype. There was otherwise no temporal or genetic clustering of the corresponding HIV sequences. CONCLUSIONS: The origin of sexually acquired acute HCV infections in HIV-positive MSM was diverse and not directly linked with local IDU. The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated.
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spelling pubmed-45286972015-08-08 Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong Chan, Denise P. Lin, Ada W. Wong, Ka Hing Wong, Ngai Sze Lee, Shui Shan Virol J Short Report BACKGROUND: Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV infection in HIV-positive MSM in Hong Kong using a molecular approach. FINDINGS: We retrospectively examined 24 HIV-positive MSM with acute HCV infection diagnosed between 2009 and 2014 in Hong Kong. Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients. Genotype 3a was the most prevalent as identified in 14 (63.6 %) MSM, followed by 1a in 4 (18.2 %), 6a in 2 (9.1 %), and 1each (4.5 %) for 1b and 2a. The high prevalence of genotype 3a in MSM was in stark contrast to its rarity among HCV infected injection drug users (IDU) in Hong Kong. Phylogenetic analyses revealed a monophyletic HCV-3a cluster composing of MSM without injection history, and a homologous pair with HCV-6a genotype. There was otherwise no temporal or genetic clustering of the corresponding HIV sequences. CONCLUSIONS: The origin of sexually acquired acute HCV infections in HIV-positive MSM was diverse and not directly linked with local IDU. The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated. BioMed Central 2015-08-08 /pmc/articles/PMC4528697/ /pubmed/26253209 http://dx.doi.org/10.1186/s12985-015-0355-8 Text en © Chan et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Chan, Denise P.
Lin, Ada W.
Wong, Ka Hing
Wong, Ngai Sze
Lee, Shui Shan
Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong
title Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong
title_full Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong
title_fullStr Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong
title_full_unstemmed Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong
title_short Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong
title_sort diverse origins of hepatitis c virus in hiv co-infected men who have sex with men in hong kong
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528697/
https://www.ncbi.nlm.nih.gov/pubmed/26253209
http://dx.doi.org/10.1186/s12985-015-0355-8
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