Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management

Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mecha...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhesi, Sumandeep, Chu, Michael P., Blevins, Gregg, Paterson, Ian, Larratt, Loree, Oudit, Gavin Y., Kim, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528786/
https://www.ncbi.nlm.nih.gov/pubmed/26425570
http://dx.doi.org/10.1177/2324709613480346
Descripción
Sumario:Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and risk factors for this important clinical entity and propose early detection and management strategies.

Ejemplares similares