Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management

Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mecha...

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Detalles Bibliográficos
Autores principales: Dhesi, Sumandeep, Chu, Michael P., Blevins, Gregg, Paterson, Ian, Larratt, Loree, Oudit, Gavin Y., Kim, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528786/
https://www.ncbi.nlm.nih.gov/pubmed/26425570
http://dx.doi.org/10.1177/2324709613480346
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author Dhesi, Sumandeep
Chu, Michael P.
Blevins, Gregg
Paterson, Ian
Larratt, Loree
Oudit, Gavin Y.
Kim, Daniel H.
author_facet Dhesi, Sumandeep
Chu, Michael P.
Blevins, Gregg
Paterson, Ian
Larratt, Loree
Oudit, Gavin Y.
Kim, Daniel H.
author_sort Dhesi, Sumandeep
collection PubMed
description Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and risk factors for this important clinical entity and propose early detection and management strategies.
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spelling pubmed-45287862015-09-30 Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management Dhesi, Sumandeep Chu, Michael P. Blevins, Gregg Paterson, Ian Larratt, Loree Oudit, Gavin Y. Kim, Daniel H. J Investig Med High Impact Case Rep Article Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and risk factors for this important clinical entity and propose early detection and management strategies. SAGE Publications 2013-01-01 /pmc/articles/PMC4528786/ /pubmed/26425570 http://dx.doi.org/10.1177/2324709613480346 Text en © 2013 American Federation for Medical Research http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Article
Dhesi, Sumandeep
Chu, Michael P.
Blevins, Gregg
Paterson, Ian
Larratt, Loree
Oudit, Gavin Y.
Kim, Daniel H.
Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management
title Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management
title_full Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management
title_fullStr Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management
title_full_unstemmed Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management
title_short Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management
title_sort cyclophosphamide-induced cardiomyopathy: a case report, review, and recommendations for management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528786/
https://www.ncbi.nlm.nih.gov/pubmed/26425570
http://dx.doi.org/10.1177/2324709613480346
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