Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report

Glatiramer acetate (GA, Copaxone) is an approved drug for the treatment of relapsing–remitting multiple sclerosis. Most common side effects observed with GA are local injection site reactions, which can include pain, swelling, or redness. However, systemic adverse event such as hepatotoxicity relate...

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Detalles Bibliográficos
Autores principales: Onmez, Attila, Eminler, Ahmet Tarik, Ergenç, Hasan, Baykara, Meltem, Uslan, Ihsan, Tamer, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528838/
https://www.ncbi.nlm.nih.gov/pubmed/26425591
http://dx.doi.org/10.1177/2324709613517493
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author Onmez, Attila
Eminler, Ahmet Tarik
Ergenç, Hasan
Baykara, Meltem
Uslan, Ihsan
Tamer, Ali
author_facet Onmez, Attila
Eminler, Ahmet Tarik
Ergenç, Hasan
Baykara, Meltem
Uslan, Ihsan
Tamer, Ali
author_sort Onmez, Attila
collection PubMed
description Glatiramer acetate (GA, Copaxone) is an approved drug for the treatment of relapsing–remitting multiple sclerosis. Most common side effects observed with GA are local injection site reactions, which can include pain, swelling, or redness. However, systemic adverse event such as hepatotoxicity related to GA is rarely seen. In this report, we present a case of GA-induced toxic hepatitis associated with cholestatic and hepatocellular damage.
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spelling pubmed-45288382015-09-30 Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report Onmez, Attila Eminler, Ahmet Tarik Ergenç, Hasan Baykara, Meltem Uslan, Ihsan Tamer, Ali J Investig Med High Impact Case Rep Case Report Glatiramer acetate (GA, Copaxone) is an approved drug for the treatment of relapsing–remitting multiple sclerosis. Most common side effects observed with GA are local injection site reactions, which can include pain, swelling, or redness. However, systemic adverse event such as hepatotoxicity related to GA is rarely seen. In this report, we present a case of GA-induced toxic hepatitis associated with cholestatic and hepatocellular damage. SAGE Publications 2013-12-17 /pmc/articles/PMC4528838/ /pubmed/26425591 http://dx.doi.org/10.1177/2324709613517493 Text en © 2013 American Federation for Medical Research http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Case Report
Onmez, Attila
Eminler, Ahmet Tarik
Ergenç, Hasan
Baykara, Meltem
Uslan, Ihsan
Tamer, Ali
Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report
title Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report
title_full Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report
title_fullStr Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report
title_full_unstemmed Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report
title_short Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report
title_sort drug-induced liver injury by glatiramer acetate used for treatment of multiple sclerosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528838/
https://www.ncbi.nlm.nih.gov/pubmed/26425591
http://dx.doi.org/10.1177/2324709613517493
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