Cargando…

A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin

Background. High prevalence of autoantibodies to the calcium-binding, endoplasmic reticulum chaperone protein calreticulin has been reported in various autoimmune and parasitic diseases. It has been reported that adenomyosis is associated with the presence of autoantibodies, in particular to phospho...

Descripción completa

Detalles Bibliográficos
Autores principales: Gude, Neil M., Stevenson, Janet L., Sheehan, Penelope M., Brennecke, Shaun P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528842/
https://www.ncbi.nlm.nih.gov/pubmed/26425587
http://dx.doi.org/10.1177/2324709613509988
_version_ 1782384713197944832
author Gude, Neil M.
Stevenson, Janet L.
Sheehan, Penelope M.
Brennecke, Shaun P.
author_facet Gude, Neil M.
Stevenson, Janet L.
Sheehan, Penelope M.
Brennecke, Shaun P.
author_sort Gude, Neil M.
collection PubMed
description Background. High prevalence of autoantibodies to the calcium-binding, endoplasmic reticulum chaperone protein calreticulin has been reported in various autoimmune and parasitic diseases. It has been reported that adenomyosis is associated with the presence of autoantibodies, in particular to phospholipids; however, it is not known whether it is associated with autoimmunity to calreticulin. Results. A 35-year-old gravida 4 para 4 woman presented with a history of many years of intractable menorrhagia. Histopathological examination of a subsequent hysterectomy specimen revealed a bulky uterus, a poorly developed secretory endometrium with decidualization of the stroma and chronic endometritis, as well as the presence of adenomyosis uteri. IgG autoantibodies to calreticulin were measured in the plasma of this and 234 other patients. Nine (3.8%) patients tested positive. The titer of anticalreticulin IgG autoantibody in the sole case with adenomyosis was approximately 8 times the average of other positive-testing samples. Conclusions. The etiology of adenomyosis is unclear. The presence of a high titer, blocking anticalreticulin autoantibody may directly increase the risk that adenomyosis might develop. It is also possible that the expansion of endometrial glandular tissue, as well as elevated estrogens, during adenomyosis may lead to elevated calreticulin, which induces an autoimmune reaction to it. Further study is required to determine whether there is a significant association between adenomyosis and the prevalence of calreticulin autoantibodies.
format Online
Article
Text
id pubmed-4528842
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-45288422015-09-30 A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin Gude, Neil M. Stevenson, Janet L. Sheehan, Penelope M. Brennecke, Shaun P. J Investig Med High Impact Case Rep Article Background. High prevalence of autoantibodies to the calcium-binding, endoplasmic reticulum chaperone protein calreticulin has been reported in various autoimmune and parasitic diseases. It has been reported that adenomyosis is associated with the presence of autoantibodies, in particular to phospholipids; however, it is not known whether it is associated with autoimmunity to calreticulin. Results. A 35-year-old gravida 4 para 4 woman presented with a history of many years of intractable menorrhagia. Histopathological examination of a subsequent hysterectomy specimen revealed a bulky uterus, a poorly developed secretory endometrium with decidualization of the stroma and chronic endometritis, as well as the presence of adenomyosis uteri. IgG autoantibodies to calreticulin were measured in the plasma of this and 234 other patients. Nine (3.8%) patients tested positive. The titer of anticalreticulin IgG autoantibody in the sole case with adenomyosis was approximately 8 times the average of other positive-testing samples. Conclusions. The etiology of adenomyosis is unclear. The presence of a high titer, blocking anticalreticulin autoantibody may directly increase the risk that adenomyosis might develop. It is also possible that the expansion of endometrial glandular tissue, as well as elevated estrogens, during adenomyosis may lead to elevated calreticulin, which induces an autoimmune reaction to it. Further study is required to determine whether there is a significant association between adenomyosis and the prevalence of calreticulin autoantibodies. SAGE Publications 2013-10-23 /pmc/articles/PMC4528842/ /pubmed/26425587 http://dx.doi.org/10.1177/2324709613509988 Text en © 2013 American Federation for Medical Research http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Article
Gude, Neil M.
Stevenson, Janet L.
Sheehan, Penelope M.
Brennecke, Shaun P.
A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
title A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
title_full A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
title_fullStr A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
title_full_unstemmed A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
title_short A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
title_sort case of adenomyosis with a high titer of igg autoantibody to calreticulin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528842/
https://www.ncbi.nlm.nih.gov/pubmed/26425587
http://dx.doi.org/10.1177/2324709613509988
work_keys_str_mv AT gudeneilm acaseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT stevensonjanetl acaseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT sheehanpenelopem acaseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT brenneckeshaunp acaseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT gudeneilm caseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT stevensonjanetl caseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT sheehanpenelopem caseofadenomyosiswithahightiterofiggautoantibodytocalreticulin
AT brenneckeshaunp caseofadenomyosiswithahightiterofiggautoantibodytocalreticulin