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Tumor Lysis Syndrome in a Retroperitoneal Sarcoma

In the present case, a 49-year-old white female presented to the clinic with a 2-month history of nausea, vomiting, and right upper quadrant pain. On examination a 3-cm mass on the right anterior scalene muscle was noted. A computed tomography scan was performed revealing a 8.7 × 7.7 × 6.1 cm retrop...

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Autores principales: Zakharia, Yousef, Mansour, Joshua, Vasireddi, Srinivasa, Zakharia, Kais, Fatakhov, Eduard, Koch, Christopher, Hrinczenko, Borys
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528897/
https://www.ncbi.nlm.nih.gov/pubmed/26425616
http://dx.doi.org/10.1177/2324709614542340
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author Zakharia, Yousef
Mansour, Joshua
Vasireddi, Srinivasa
Zakharia, Kais
Fatakhov, Eduard
Koch, Christopher
Hrinczenko, Borys
author_facet Zakharia, Yousef
Mansour, Joshua
Vasireddi, Srinivasa
Zakharia, Kais
Fatakhov, Eduard
Koch, Christopher
Hrinczenko, Borys
author_sort Zakharia, Yousef
collection PubMed
description In the present case, a 49-year-old white female presented to the clinic with a 2-month history of nausea, vomiting, and right upper quadrant pain. On examination a 3-cm mass on the right anterior scalene muscle was noted. A computed tomography scan was performed revealing a 8.7 × 7.7 × 6.1 cm retroperitoneal mass with possible invasion of the inferior vena cava and right renal and left common iliac veins. An excisional biopsy was performed with pathology compatible with spindle cell sarcoma. The patient was then sent for follow-up at the sarcoma clinic as an outpatient. However, before chemotherapy was to be started the patient would be admitted to the hospital with progressively worse nausea and vomiting. At that time the patient’s lab work showed lactic acidosis, acute renal failure, hyperuricemia, hyperphosphatemia, and hypocalcemia, which met the Cairo–Bishop criteria for tumor lysis syndrome (TLS). The patient was admitted to the intensive care unit and kidney dialysis initiated. The patient would become progressively obtunded at which time the family opted for hospice care. The patient eventually succumbed peacefully 3 days after her last admission. In this case report, we briefly review the literature on TLS in solid tumors, and we present a rare case of spontaneous TLS in a retroperitoneal sarcoma.
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spelling pubmed-45288972015-09-30 Tumor Lysis Syndrome in a Retroperitoneal Sarcoma Zakharia, Yousef Mansour, Joshua Vasireddi, Srinivasa Zakharia, Kais Fatakhov, Eduard Koch, Christopher Hrinczenko, Borys J Investig Med High Impact Case Rep Article In the present case, a 49-year-old white female presented to the clinic with a 2-month history of nausea, vomiting, and right upper quadrant pain. On examination a 3-cm mass on the right anterior scalene muscle was noted. A computed tomography scan was performed revealing a 8.7 × 7.7 × 6.1 cm retroperitoneal mass with possible invasion of the inferior vena cava and right renal and left common iliac veins. An excisional biopsy was performed with pathology compatible with spindle cell sarcoma. The patient was then sent for follow-up at the sarcoma clinic as an outpatient. However, before chemotherapy was to be started the patient would be admitted to the hospital with progressively worse nausea and vomiting. At that time the patient’s lab work showed lactic acidosis, acute renal failure, hyperuricemia, hyperphosphatemia, and hypocalcemia, which met the Cairo–Bishop criteria for tumor lysis syndrome (TLS). The patient was admitted to the intensive care unit and kidney dialysis initiated. The patient would become progressively obtunded at which time the family opted for hospice care. The patient eventually succumbed peacefully 3 days after her last admission. In this case report, we briefly review the literature on TLS in solid tumors, and we present a rare case of spontaneous TLS in a retroperitoneal sarcoma. SAGE Publications 2014-07-04 /pmc/articles/PMC4528897/ /pubmed/26425616 http://dx.doi.org/10.1177/2324709614542340 Text en © 2014 American Federation for Medical Research http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Article
Zakharia, Yousef
Mansour, Joshua
Vasireddi, Srinivasa
Zakharia, Kais
Fatakhov, Eduard
Koch, Christopher
Hrinczenko, Borys
Tumor Lysis Syndrome in a Retroperitoneal Sarcoma
title Tumor Lysis Syndrome in a Retroperitoneal Sarcoma
title_full Tumor Lysis Syndrome in a Retroperitoneal Sarcoma
title_fullStr Tumor Lysis Syndrome in a Retroperitoneal Sarcoma
title_full_unstemmed Tumor Lysis Syndrome in a Retroperitoneal Sarcoma
title_short Tumor Lysis Syndrome in a Retroperitoneal Sarcoma
title_sort tumor lysis syndrome in a retroperitoneal sarcoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528897/
https://www.ncbi.nlm.nih.gov/pubmed/26425616
http://dx.doi.org/10.1177/2324709614542340
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