Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice

Long-lived plasma cells (LLPCs) are an unmet therapeutic challenge, and developing strategies for their targeting is an emerging goal of autoantibody-mediated diseases such as systemic lupus erythematosus (SLE). It was previously shown that plasma cells can be depleted by agents such as bortezomib (...

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Detalles Bibliográficos
Autores principales: Khodadadi, Laleh, Cheng, Qingyu, Alexander, Tobias, Sercan-Alp, Özen, Klotsche, Jens, Radbruch, Andreas, Hiepe, Falk, Hoyer, Bimba F., Taddeo, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529137/
https://www.ncbi.nlm.nih.gov/pubmed/26252021
http://dx.doi.org/10.1371/journal.pone.0135081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529137/
https://www.ncbi.nlm.nih.gov/pubmed/26252021
http://dx.doi.org/10.1371/journal.pone.0135081

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