PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease

Poly (ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that is involved in physiological processes as DNA repair, genomic stability, and apoptosis. Moreover, published studies demonstrated that PARP-1 mediates necrotic cell death in response to excessive DNA damage under certain pathological co...

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Detalles Bibliográficos
Autores principales: Cardinale, Antonella, Paldino, Emanuela, Giampà, Carmela, Bernardi, Giorgio, Fusco, Francesca R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529170/
https://www.ncbi.nlm.nih.gov/pubmed/26252217
http://dx.doi.org/10.1371/journal.pone.0134482

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