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The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface

The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here the oligomeric state of the functional ASIC1 in situ at the cell surface. The oligomeric states of functional ASIC1a and mutants with additional cysteines introduced in the extracellular pore vestibule...

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Detalles Bibliográficos
Autores principales:	van Bemmelen, Miguel Xavier, Huser, Delphine, Gautschi, Ivan, Schild, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529235/ https://www.ncbi.nlm.nih.gov/pubmed/26252376 http://dx.doi.org/10.1371/journal.pone.0135191

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