A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver

NADPH oxidases (NOXs) are a predominant mediator of redox homeostasis in hepatic stellate cells (HSCs), and oxidative stress plays an important role in the pathogenesis of liver fibrosis. Ursolic acid (UA) is a pentacyclic triterpenoid with various pharmacological activities, but the molecular targe...

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Detalles Bibliográficos
Autores principales: He, Wenhua, Shi, Feng, Zhou, Zhi-Wei, Li, Bimin, Zhang, Kunhe, Zhang, Xinhua, Ouyang, Canhui, Zhou, Shu-Feng, Zhu, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529259/
https://www.ncbi.nlm.nih.gov/pubmed/26347199
http://dx.doi.org/10.2147/DDDT.S85426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529259/
https://www.ncbi.nlm.nih.gov/pubmed/26347199
http://dx.doi.org/10.2147/DDDT.S85426

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