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Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor involved in both solid and hematological tumors. About 80% of ALK-positive anaplastic large-cell lymphoma (ALCL) cases are characterized by the t(2;5)(p23;q35) translocation, encoding for the aberrant fusion protein nucleophosmin (NPM)-A...

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Detalles Bibliográficos
Autores principales:	Fontana, Diletta, Ceccon, Monica, Gambacorti-Passerini, Carlo, Mologni, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529334/ https://www.ncbi.nlm.nih.gov/pubmed/25727400 http://dx.doi.org/10.1002/cam4.413

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