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Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study

OBJECTIVES: The objectives are to examine the reproducibility of functional MR imaging in children with solid tumours using quantitative parameters derived from diffusion-weighted (DW-) and dynamic contrast enhanced (DCE-) MRI. METHODS: Patients under 16-years-of age with confirmed diagnosis of soli...

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Autores principales: Miyazaki, Keiko, Jerome, Neil P., Collins, David J., Orton, Matthew R., d’Arcy, James A., Wallace, Toni, Moreno, Lucas, Pearson, Andrew D. J., Marshall, Lynley V., Carceller, Fernando, Leach, Martin O., Zacharoulis, Stergios, Koh, Dow-Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529450/
https://www.ncbi.nlm.nih.gov/pubmed/25773937
http://dx.doi.org/10.1007/s00330-015-3666-7
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author Miyazaki, Keiko
Jerome, Neil P.
Collins, David J.
Orton, Matthew R.
d’Arcy, James A.
Wallace, Toni
Moreno, Lucas
Pearson, Andrew D. J.
Marshall, Lynley V.
Carceller, Fernando
Leach, Martin O.
Zacharoulis, Stergios
Koh, Dow-Mu
author_facet Miyazaki, Keiko
Jerome, Neil P.
Collins, David J.
Orton, Matthew R.
d’Arcy, James A.
Wallace, Toni
Moreno, Lucas
Pearson, Andrew D. J.
Marshall, Lynley V.
Carceller, Fernando
Leach, Martin O.
Zacharoulis, Stergios
Koh, Dow-Mu
author_sort Miyazaki, Keiko
collection PubMed
description OBJECTIVES: The objectives are to examine the reproducibility of functional MR imaging in children with solid tumours using quantitative parameters derived from diffusion-weighted (DW-) and dynamic contrast enhanced (DCE-) MRI. METHODS: Patients under 16-years-of age with confirmed diagnosis of solid tumours (n = 17) underwent free-breathing DW-MRI and DCE-MRI on a 1.5 T system, repeated 24 hours later. DW-MRI (6 b-values, 0-1000 sec/mm(2)) enabled monoexponential apparent diffusion coefficient estimation using all (ADC(0-1000)) and only ≥100 sec/mm(2) (ADC(100-1000)) b-values. DCE-MRI was used to derive the transfer constant (K(trans)), the efflux constant (k(ep)), the extracellular extravascular volume (v(e)), and the plasma fraction (v(p)), using a study cohort arterial input function (AIF) and the extended Tofts model. Initial area under the gadolinium enhancement curve and pre-contrast T(1) were also calculated. Percentage coefficients of variation (CV) of all parameters were calculated. RESULTS: The most reproducible cohort parameters were ADC(100-1000) (CV = 3.26 %), pre-contrast T(1) (CV = 6.21 %), and K(trans) (CV = 15.23 %). The ADC(100-1000) was more reproducible than ADC(0-1000), especially extracranially (CV = 2.40 % vs. 2.78 %). The AIF (n = 9) derived from this paediatric population exhibited sharper and earlier first-pass and recirculation peaks compared with the literature’s adult population average. CONCLUSIONS: Free-breathing functional imaging protocols including DW-MRI and DCE-MRI are well-tolerated in children aged 6 - 15 with good to moderate measurement reproducibility. KEY POINTS: • Diffusion MRI protocol is feasible and well-tolerated in a paediatric oncology population. • DCE-MRI for pharmacokinetic evaluation is feasible and well tolerated in a paediatric oncology population. • Paediatric arterial input function (AIF) shows systematic differences from the adult population-average AIF. • Variation of quantitative parameters from paired functional MRI measurements were within 20 %.
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spelling pubmed-45294502015-08-11 Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study Miyazaki, Keiko Jerome, Neil P. Collins, David J. Orton, Matthew R. d’Arcy, James A. Wallace, Toni Moreno, Lucas Pearson, Andrew D. J. Marshall, Lynley V. Carceller, Fernando Leach, Martin O. Zacharoulis, Stergios Koh, Dow-Mu Eur Radiol Pediatric OBJECTIVES: The objectives are to examine the reproducibility of functional MR imaging in children with solid tumours using quantitative parameters derived from diffusion-weighted (DW-) and dynamic contrast enhanced (DCE-) MRI. METHODS: Patients under 16-years-of age with confirmed diagnosis of solid tumours (n = 17) underwent free-breathing DW-MRI and DCE-MRI on a 1.5 T system, repeated 24 hours later. DW-MRI (6 b-values, 0-1000 sec/mm(2)) enabled monoexponential apparent diffusion coefficient estimation using all (ADC(0-1000)) and only ≥100 sec/mm(2) (ADC(100-1000)) b-values. DCE-MRI was used to derive the transfer constant (K(trans)), the efflux constant (k(ep)), the extracellular extravascular volume (v(e)), and the plasma fraction (v(p)), using a study cohort arterial input function (AIF) and the extended Tofts model. Initial area under the gadolinium enhancement curve and pre-contrast T(1) were also calculated. Percentage coefficients of variation (CV) of all parameters were calculated. RESULTS: The most reproducible cohort parameters were ADC(100-1000) (CV = 3.26 %), pre-contrast T(1) (CV = 6.21 %), and K(trans) (CV = 15.23 %). The ADC(100-1000) was more reproducible than ADC(0-1000), especially extracranially (CV = 2.40 % vs. 2.78 %). The AIF (n = 9) derived from this paediatric population exhibited sharper and earlier first-pass and recirculation peaks compared with the literature’s adult population average. CONCLUSIONS: Free-breathing functional imaging protocols including DW-MRI and DCE-MRI are well-tolerated in children aged 6 - 15 with good to moderate measurement reproducibility. KEY POINTS: • Diffusion MRI protocol is feasible and well-tolerated in a paediatric oncology population. • DCE-MRI for pharmacokinetic evaluation is feasible and well tolerated in a paediatric oncology population. • Paediatric arterial input function (AIF) shows systematic differences from the adult population-average AIF. • Variation of quantitative parameters from paired functional MRI measurements were within 20 %. Springer Berlin Heidelberg 2015-03-15 2015 /pmc/articles/PMC4529450/ /pubmed/25773937 http://dx.doi.org/10.1007/s00330-015-3666-7 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Pediatric
Miyazaki, Keiko
Jerome, Neil P.
Collins, David J.
Orton, Matthew R.
d’Arcy, James A.
Wallace, Toni
Moreno, Lucas
Pearson, Andrew D. J.
Marshall, Lynley V.
Carceller, Fernando
Leach, Martin O.
Zacharoulis, Stergios
Koh, Dow-Mu
Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
title Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
title_full Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
title_fullStr Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
title_full_unstemmed Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
title_short Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
title_sort demonstration of the reproducibility of free-breathing diffusion-weighted mri and dynamic contrast enhanced mri in children with solid tumours: a pilot study
topic Pediatric
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529450/
https://www.ncbi.nlm.nih.gov/pubmed/25773937
http://dx.doi.org/10.1007/s00330-015-3666-7
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