Cargando…

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial

OBJECTIVE: T-cell activation independently predicts mortality, poor immune recovery and non-AIDS illnesses during combination antiretroviral therapy (cART). Atorvastatin showed anti-immune activation effects among HIV-infected cART-naïve individuals. We investigated whether adjunct atorvastatin ther...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakanjako, Damalie, Ssinabulya, Isaac, Nabatanzi, Rose, Bayigga, Lois, Kiragga, Agnes, Joloba, Moses, Kaleebu, Pontiano, Kambugu, Andrew D., Kamya, Moses R., Sekaly, Rafick, Elliott, Alison, Mayanja-Kizza, Harriet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529480/ https://www.ncbi.nlm.nih.gov/pubmed/25441397 http://dx.doi.org/10.1111/tmi.12442

Ejemplares similares

High CD56(++)CD16(-) natural killer (NK) cells among suboptimal immune responders after four years of suppressive antiretroviral therapy in an African adult HIV treatment cohort
por: Bayigga, Lois, et al.
Publicado: (2014)

Impaired T-cell proliferation among HAART-treated adults with suboptimal CD4 recovery in an African cohort
por: Nakanjako, Damalie, et al.
Publicado: (2013)

High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort
por: Nakanjako, Damalie, et al.
Publicado: (2011)

Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort
por: Nabatanzi, Rose, et al.
Publicado: (2019)

Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African Cohort
por: Nabatanzi, Rose, et al.
Publicado: (2019)

Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
por: Nabatanzi, Rose, et al.
Publicado: (2021)

Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
por: Nabatanzi, Rose, et al.
Publicado: (2018)

Doctoral training in Uganda: evaluation of mentoring best practices at Makerere university college of health sciences
por: Nakanjako, Damalie, et al.
Publicado: (2014)

Longitudinal patients' cohorts for impactful research and HIV care at the Infectious Diseases Institute
por: Castelnuovo, Barbara, et al.
Publicado: (2022)

Low prevalence of Plasmodium falciparum antigenaemia among asymptomatic HAART-treated adults in an urban cohort in Uganda
por: Nakanjako, Damalie, et al.
Publicado: (2011)

A need to accelerate health research productivity in an African University: the case of Makerere University College of Health Sciences
por: Nakanjako, Damalie, et al.
Publicado: (2017)

Chest X-ray interpretation does not complement Xpert MTB/RIF in diagnosis of smear-negative pulmonary tuberculosis among TB-HIV co-infected adults in a resource-limited setting
por: Nakiyingi, Lydia, et al.
Publicado: (2021)

Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance
por: Nakanjako, Damalie, et al.
Publicado: (2008)

Mentorship needs at academic institutions in resource-limited settings: a survey at makerere university college of health sciences
por: Nakanjako, Damalie, et al.
Publicado: (2011)

Increased Levels of Caspase-1 and IL-1β Among Adults With Persistent Immune Activation After 12 Years of Suppressive Antiretroviral Therapy in the Infectious Diseases Institute HIV Treatment Cohort
por: Nabatanzi, Rose, et al.
Publicado: (2023)

Experiences of patients who developed oral mucositis during solid neoplasms treatment: a Ugandan qualitative study
por: Kamulegeya, Adriane, et al.
Publicado: (2021)

Extensive dental caries in a HIV positive adult patient on ART; case report and literature review
por: Kalanzi, Dunstan, et al.
Publicado: (2018)

Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90% of HIV-Infected Individuals
por: Ingabire, Prossie Merab, et al.
Publicado: (2019)

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda
por: Nakiyingi, Lydia, et al.
Publicado: (2015)

A decade of antiretroviral therapy in Uganda: what are the emerging causes of death?
por: Kiragga, Agnes N., et al.
Publicado: (2019)

First-line antiretroviral therapy durability in a 10-year cohort of naïve adults started on treatment in Uganda
por: Castelnuovo, Barbara, et al.
Publicado: (2016)

Predictors for MTB Culture-Positivity among HIV-Infected Smear-Negative Presumptive Tuberculosis Patients in Uganda: Application of New Tuberculosis Diagnostic Technology
por: Nakiyingi, Lydia, et al.
Publicado: (2015)

Infectious Diseases Institute at Makerere University College of Health Sciences: a case study of a sustainable capacity building model for health care, research and training
por: Nakanjako, Damalie, et al.
Publicado: (2022)

Prevalence and factors associated with dental caries in patients attending an HIV care clinic in Uganda: a cross sectional study
por: Kalanzi, Dunstan, et al.
Publicado: (2019)

Immunology in Africa
por: Cose, Stephen, et al.
Publicado: (2015)

Mobile Phone-based Intervention to promote un-interrupted HIV treatment during the COVID-19 pandemic
por: Nakanjako, Damalie, et al.
Publicado: (2022)

Risky sexual behavior among patients on long-term antiretroviral therapy: a prospective cohort study in urban and rural Uganda
por: Okoboi, Stephen, et al.
Publicado: (2018)

Dental Caries Pattern and Treatment Needs among Ugandan Adolescent Students: A Cross-Sectional Study
por: Ndagire, Barbara, et al.
Publicado: (2020)

Evaluation of Cepheid's Xpert MTB/RIF Test on Pleural Fluid in the Diagnosis of Pleural Tuberculosis in a High Prevalence HIV/TB Setting
por: Lusiba, John K., et al.
Publicado: (2014)

Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings
por: Kiragga, Agnes N, et al.
Publicado: (2010)

Subclinical Atherosclerosis among HIV-Infected Adults Attending HIV/AIDS Care at Two Large Ambulatory HIV Clinics in Uganda
por: Ssinabulya, Isaac, et al.
Publicado: (2014)

Outcomes in a Cohort of Patients Started on Antiretroviral Treatment and Followed up for a Decade in an Urban Clinic in Uganda
por: Castelnuovo, Barbara, et al.
Publicado: (2015)

Burden of tuberculosis disease among adolescents in a rural cohort in Eastern Uganda
por: Waako, James, et al.
Publicado: (2013)

Genotypic diversity among multidrug resistant Pseudomonas aeruginosa and Acinetobacter species at Mulago Hospital in Kampala, Uganda
por: Kateete, David P., et al.
Publicado: (2017)

Feasibility of establishing a biosafety level 3 tuberculosis culture laboratory of acceptable quality standards in a resource-limited setting: an experience from Uganda
por: Ssengooba, Willy, et al.
Publicado: (2015)

Incident Tuberculosis during Antiretroviral Therapy Contributes to Suboptimal Immune Reconstitution in a Large Urban HIV Clinic in Sub-Saharan Africa
por: Hermans, Sabine M., et al.
Publicado: (2010)

Sub-Optimal Vitamin B-12 Levels among ART-Naïve HIV-Positive Individuals in an Urban Cohort in Uganda
por: Semeere, Aggrey S., et al.
Publicado: (2012)

Intra-Facility Linkage of HIV-Positive Mothers and HIV-Exposed Babies into HIV Chronic Care: Rural and Urban Experience in a Resource Limited Setting
por: Mugasha, Christine, et al.
Publicado: (2014)

Socioeconomic position and ten-year survival and virologic outcomes in a Ugandan HIV cohort receiving antiretroviral therapy
por: Flynn, Andrew G., et al.
Publicado: (2017)

COVID-19 may exacerbate the clinical, structural and psychological barriers to retention in care among women living with HIV in rural and peri-urban settings in Uganda
por: Nalubega, Sylivia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v6iuq0htcavhgl3o7b9quou6fb