Cargando…

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin chains by the Ube2V2–Ubc13 E2 complex is required for many important biological processes. Here we report the structure of the RING domain dimer of rat RNF4 in complex with a human Ubc13~Ub conjugate and Ube2V2. The structure has c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Branigan, Emma, Plechanovová, Anna, Jaffray, Ellis, Naismith, James H., Hay, Ronald T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529489/ https://www.ncbi.nlm.nih.gov/pubmed/26148049 http://dx.doi.org/10.1038/nsmb.3052

Ejemplares similares

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
por: Plechanovová, Anna, et al.
Publicado: (2012)

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini
por: Tatham, Michael H., et al.
Publicado: (2013)

SUMO Chain-Induced Dimerization Activates RNF4
por: Rojas-Fernandez, Alejandro, et al.
Publicado: (2014)

Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
por: Branigan, Emma, et al.
Publicado: (2020)

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking
por: Erpapazoglou, Zoi, et al.
Publicado: (2014)

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases
por: Mathur, Sunil, et al.
Publicado: (2020)

Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer
por: Murphy, Paul, et al.
Publicado: (2020)

Role of K63-linked ubiquitination in cancer
por: Cao, Liangzi, et al.
Publicado: (2022)

K63-Linked Ubiquitination in Kinase Activation and Cancer
por: Wang, Guocan, et al.
Publicado: (2012)

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4
por: Xu, Yingqi, et al.
Publicado: (2014)

A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting
por: Erpapazoglou, Zoi, et al.
Publicado: (2012)

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway
por: Lauwers, Elsa, et al.
Publicado: (2009)

The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma
por: Wang, Zhangjie, et al.
Publicado: (2023)

pVHL Mediates K63-Linked Ubiquitination of nCLU
por: Xue, Jing, et al.
Publicado: (2012)

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers
por: Bett, John S., et al.
Publicado: (2015)

Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains
por: Mikami, Toshiki, et al.
Publicado: (2023)

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy
por: Vasco Ferreira, Joao, et al.
Publicado: (2015)

K63 ubiquitination in immune signaling
por: Madiraju, Charitha, et al.
Publicado: (2022)

The Carcinogen Cadmium Activates Lysine 63 (K63)-Linked Ubiquitin-Dependent Signaling and Inhibits Selective Autophagy
por: Chargui, Abderrahman, et al.
Publicado: (2021)

The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K
por: Middleton, Adam J., et al.
Publicado: (2015)

Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition
por: Liu, Zhu, et al.
Publicado: (2015)

Functional implications of K63-linked ubiquitination in the iron deficiency response of Arabidopsis roots
por: Pan, I-Chun, et al.
Publicado: (2014)

Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair
por: Vamisetti, Ganga B., et al.
Publicado: (2022)

Ubc13: the Lys63 ubiquitin chain building machine
por: Hodge, Curtis D., et al.
Publicado: (2016)

Septins and K63 ubiquitin chains are present in separate bacterial microdomains during autophagy of entrapped Shigella
por: Lobato-Márquez, Damián, et al.
Publicado: (2023)

Beyond K48 and K63: non-canonical protein ubiquitination
por: Tracz, Michal, et al.
Publicado: (2021)

The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β Subunits
por: Moreno, Daniel, et al.
Publicado: (2010)

TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination
por: Zhu, Qingchen, et al.
Publicado: (2020)

TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination
por: Zhu, Xuefei, et al.
Publicado: (2022)

Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC
por: Guan, Hongxin, et al.
Publicado: (2020)

Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage
por: Maure, Jean-François, et al.
Publicado: (2016)

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains
por: Pluska, Lukas, et al.
Publicado: (2021)

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation
por: Ho, Yik-Khuan, et al.
Publicado: (2015)

TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome
por: Schwintzer, Lukas, et al.
Publicado: (2019)

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
por: Wang, Guihua, et al.
Publicado: (2019)

Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
por: Liu, Chun-Shan, et al.
Publicado: (2017)

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
por: Ye, Liya, et al.
Publicado: (2019)

Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase
por: Zhu, Lu, et al.
Publicado: (2022)

Ubiquitin Lys 63 chains – second-most abundant, but poorly understood in plants
por: Tomanov, Konstantin, et al.
Publicado: (2014)

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53
por: Guo, Yafei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c8ts57as0h9j592ji1ssksaq0k