Cargando…

Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response

OBJECTIVE: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intracerebroventricular (icv) administration of the non-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rojas, Jennifer M., Matsen, Miles E., Mundinger, Thomas O., Morton, Gregory J., Stefanovski, Darko, Bergman, Richard N., Kaiyala, Karl J., Taborsky, Gerald J., Schwartz, Michael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529498/ https://www.ncbi.nlm.nih.gov/pubmed/26266088 http://dx.doi.org/10.1016/j.molmet.2015.05.005

Ejemplares similares

Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain
por: Scarlett, Jarrad M., et al.
Publicado: (2019)

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents
por: Scarlett, Jarrad M., et al.
Publicado: (2016)

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
por: German, Jonathan P., et al.
Publicado: (2010)

BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production
por: Meek, Thomas H., et al.
Publicado: (2013)

Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia
por: Meek, Thomas H., et al.
Publicado: (2015)

Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver
por: Zheng, Dan, et al.
Publicado: (2009)

Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm
por: Nittala, Aparna, et al.
Publicado: (2006)

Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission
por: Brown, Jenny M., et al.
Publicado: (2021)

Response to Comment on: Stefanovski et al. Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Diabetes Care 2012;35:1015–1020
por: Stefanovski, Darko, et al.
Publicado: (2012)

MON-LB116 FGF-21 Is A Reliable Marker Of Insulin Resistance Before The Occurrence Of Glucose Intolerance
por: sawah, ahmed, et al.
Publicado: (2020)

The p75 Neurotrophin Receptor Is Required for the Major Loss of Sympathetic Nerves From Islets Under Autoimmune Attack
por: Taborsky, Gerald J., et al.
Publicado: (2014)

Critical Role of the Mesenteric Depot Versus Other Intra-abdominal Adipose Depots in the Development of Insulin Resistance in Young Rats
por: Catalano, Karyn J., et al.
Publicado: (2010)

Leptin Signaling Is Required for Adaptive Changes in Food Intake, but Not Energy Expenditure, in Response to Different Thermal Conditions
por: Kaiyala, Karl J., et al.
Publicado: (2015)

Toward a More Complete (and Less Controversial) Understanding of Energy Expenditure and Its Role in Obesity Pathogenesis
por: Kaiyala, Karl J., et al.
Publicado: (2011)

Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD
por: Patton, Ashley, et al.
Publicado: (2018)

Blueberries’ Impact on Insulin Resistance and Glucose Intolerance
por: Stull, April J.
Publicado: (2016)

Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
por: Kaiyala, Karl J., et al.
Publicado: (2010)

Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves
por: Mundinger, Thomas O., et al.
Publicado: (2016)

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism()
por: Marcelin, Geneviève, et al.
Publicado: (2013)

Proinsulin is sensitive to reflect glucose intolerance
por: Nakamura, Akinobu, et al.
Publicado: (2019)

Increased Myocardial Uptake of Dietary Fatty Acids Linked to Cardiac Dysfunction in Glucose-Intolerant Humans
por: Labbé, Sébastien M., et al.
Publicado: (2012)

Determinants of Impaired Fasting Glucose Versus Glucose Intolerance in Polycystic Ovary Syndrome
por: Karakas, Sidika E., et al.
Publicado: (2010)

αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance
por: Toft, Daniel J., et al.
Publicado: (2016)

Intestinal Ralstonia pickettii augments glucose intolerance in obesity
por: Udayappan, Shanthadevi D., et al.
Publicado: (2017)

Mathematical Model for the Contribution of Individual Organs to Non-Zero Y-Intercepts in Single and Multi-Compartment Linear Models of Whole-Body Energy Expenditure
por: Kaiyala, Karl J.
Publicado: (2014)

What does indirect calorimetry really tell us?
por: Kaiyala, Karl J.
Publicado: (2014)

Fractal analysis of thermoregulatory complexity
por: Kaiyala, Karl J.
Publicado: (2016)

Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea
por: Polak, Jan, et al.
Publicado: (2018)

Physiological role for leptin in the control of thermal conductance
por: Kaiyala, Karl J., et al.
Publicado: (2016)

Response to Leptin-deficient mice are not hypothermic, they are anapyrexic
por: Kaiyala, Karl J., et al.
Publicado: (2017)

METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
por: Kalyani, Rita, et al.
Publicado: (2022)

The pathophysiology of glucose intolerance in newly diagnosed, untreated T2DM
por: Dunseath, Gareth J., et al.
Publicado: (2021)

Insulin Action, Glucose Homeostasis and Free Fatty Acid Metabolism: Insights From a Novel Model
por: Stefanovski, Darko, et al.
Publicado: (2021)

Glucose Intolerance in Pregnancy and Future Risk of Pre-Diabetes or Diabetes
por: Retnakaran, Ravi, et al.
Publicado: (2008)

Oral Glucose Tolerance Test for the Screening of Glucose Intolerance Long Term Post‐Heart Transplantation
por: Roest, Stefan, et al.
Publicado: (2022)

Corrigendum: Insulin Action, Glucose Homeostasis and Free Fatty Acid Metabolism: Insights From a Novel Model
por: Stefanovski, Darko, et al.
Publicado: (2021)

1-h Glucose During Oral Glucose Tolerance Test Predicts Hyperglycemia Relapse-Free Survival in Obese Black Patients With Hyperglycemic Crises
por: Jagannathan, Ram, et al.
Publicado: (2022)

Exendin-(9-39) Effects on Glucose and Insulin in Children With Congenital Hyperinsulinism During Fasting and During a Meal and a Protein Challenge
por: Stefanovski, Darko, et al.
Publicado: (2022)

Sox9-Haploinsufficiency Causes Glucose Intolerance in Mice
por: Dubois, Claire L., et al.
Publicado: (2011)

Exenatide improves glucocorticoid-induced glucose intolerance in mice
por: Zhao, Ruiying, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_548afs8mrf8h50fierprkj8b8o