Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions

Hydrophilic coordinating chiral ionic liquids with an amino alcohol substructure were developed and efficiently applied to the asymmetric reduction of ketones. Their careful design and adaptability to the desired reaction conditions allow for these chiral ionic liquids to be used as the sole source...

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Autores principales: Vasiloiu, Maria, Gaertner, Peter, Zirbs, Ronald, Bica, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529664/
https://www.ncbi.nlm.nih.gov/pubmed/26279638
http://dx.doi.org/10.1002/ejoc.201403555
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author Vasiloiu, Maria
Gaertner, Peter
Zirbs, Ronald
Bica, Katharina
author_facet Vasiloiu, Maria
Gaertner, Peter
Zirbs, Ronald
Bica, Katharina
author_sort Vasiloiu, Maria
collection PubMed
description Hydrophilic coordinating chiral ionic liquids with an amino alcohol substructure were developed and efficiently applied to the asymmetric reduction of ketones. Their careful design and adaptability to the desired reaction conditions allow for these chiral ionic liquids to be used as the sole source of chirality in a ruthenium-catalyzed transfer hydrogenation reaction of aromatic ketones. When used in this reaction system, these chiral ionic liquids afforded excellent yields and high enantioselectivities.
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spelling pubmed-45296642015-08-13 Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions Vasiloiu, Maria Gaertner, Peter Zirbs, Ronald Bica, Katharina European J Org Chem Full Papers Hydrophilic coordinating chiral ionic liquids with an amino alcohol substructure were developed and efficiently applied to the asymmetric reduction of ketones. Their careful design and adaptability to the desired reaction conditions allow for these chiral ionic liquids to be used as the sole source of chirality in a ruthenium-catalyzed transfer hydrogenation reaction of aromatic ketones. When used in this reaction system, these chiral ionic liquids afforded excellent yields and high enantioselectivities. WILEY-VCH Verlag 2015-04 2015-02-20 /pmc/articles/PMC4529664/ /pubmed/26279638 http://dx.doi.org/10.1002/ejoc.201403555 Text en © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Vasiloiu, Maria
Gaertner, Peter
Zirbs, Ronald
Bica, Katharina
Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
title Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
title_full Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
title_fullStr Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
title_full_unstemmed Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
title_short Coordinating Chiral Ionic Liquids: Design, Synthesis, and Application in Asymmetric Transfer Hydrogenation under Aqueous Conditions
title_sort coordinating chiral ionic liquids: design, synthesis, and application in asymmetric transfer hydrogenation under aqueous conditions
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529664/
https://www.ncbi.nlm.nih.gov/pubmed/26279638
http://dx.doi.org/10.1002/ejoc.201403555
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