Cargando…
Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats
BACKGROUND: In Chinese medicine, dual effects on target organs are considered a primary characteristic of acupoint. Acupoints may be classified as heterotopic or homotopic in terms of spinal segmental innervation: homotopic acupoints contain afferent innervation in the same segment from which effere...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529689/ https://www.ncbi.nlm.nih.gov/pubmed/26253168 http://dx.doi.org/10.1186/s12906-015-0781-6 |
_version_ | 1782384817847926784 |
---|---|
author | Qin, Qingguang Mo, Qian Liu, Kun He, Xun Gao, Xinyan Zhu, Bing |
author_facet | Qin, Qingguang Mo, Qian Liu, Kun He, Xun Gao, Xinyan Zhu, Bing |
author_sort | Qin, Qingguang |
collection | PubMed |
description | BACKGROUND: In Chinese medicine, dual effects on target organs are considered a primary characteristic of acupoint. Acupoints may be classified as heterotopic or homotopic in terms of spinal segmental innervation: homotopic acupoints contain afferent innervation in the same segment from which efferent fibers innervate target visceral organs, and heterotopic acupoints utilize different spinal segments to innervate target visceral organs than the segment receiving the afferent signal. It is well-known that dual effects of acupuncture on the bladder can be generated based on different states of the bladder, however, the dual effects of single acupoint stimulation and acupoint site-specificity (homotopic acupoints and heterotopic acupoints) on the bladder have yet to be investigated. METHODS: Twenty Sprague-Dawley rats were anesthetized and the intravesical pressure was measured via a manometric balloon inserted into the bladder. The acupuncture needle was separately inserted to a depth of 4 mm at the acupoints RN1 (Huiyin), RN3 (Zhongji), BL28 (Pangguangshu), BL32 (Ciliao), RN2 (Qugu) or BL23 (Shenshu), and manually rotated right then left with a frequency of 2 Hz for 1 min. Following acupuncture stimulation, bladder pressure was recorded and compared against the pre-stimulation measurements. RESULTS: During the bladder’s active state, manual acupuncture (MA) at RN1, RN3, BL28, BL32 or RN2 inhibited bladder motility (P < 0.01). In the static bladder, MA at RN1, RN3, BL28, BL32, RN2 or BL23 increased bladder motility (P < 0.01). CONCLUSIONS: MA at homotopic acupoints may produce dual effects on bladder motility: inhibiting bladder motility when in an active state and enhancing bladder motility when in a static state. |
format | Online Article Text |
id | pubmed-4529689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45296892015-08-09 Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats Qin, Qingguang Mo, Qian Liu, Kun He, Xun Gao, Xinyan Zhu, Bing BMC Complement Altern Med Research Article BACKGROUND: In Chinese medicine, dual effects on target organs are considered a primary characteristic of acupoint. Acupoints may be classified as heterotopic or homotopic in terms of spinal segmental innervation: homotopic acupoints contain afferent innervation in the same segment from which efferent fibers innervate target visceral organs, and heterotopic acupoints utilize different spinal segments to innervate target visceral organs than the segment receiving the afferent signal. It is well-known that dual effects of acupuncture on the bladder can be generated based on different states of the bladder, however, the dual effects of single acupoint stimulation and acupoint site-specificity (homotopic acupoints and heterotopic acupoints) on the bladder have yet to be investigated. METHODS: Twenty Sprague-Dawley rats were anesthetized and the intravesical pressure was measured via a manometric balloon inserted into the bladder. The acupuncture needle was separately inserted to a depth of 4 mm at the acupoints RN1 (Huiyin), RN3 (Zhongji), BL28 (Pangguangshu), BL32 (Ciliao), RN2 (Qugu) or BL23 (Shenshu), and manually rotated right then left with a frequency of 2 Hz for 1 min. Following acupuncture stimulation, bladder pressure was recorded and compared against the pre-stimulation measurements. RESULTS: During the bladder’s active state, manual acupuncture (MA) at RN1, RN3, BL28, BL32 or RN2 inhibited bladder motility (P < 0.01). In the static bladder, MA at RN1, RN3, BL28, BL32, RN2 or BL23 increased bladder motility (P < 0.01). CONCLUSIONS: MA at homotopic acupoints may produce dual effects on bladder motility: inhibiting bladder motility when in an active state and enhancing bladder motility when in a static state. BioMed Central 2015-08-08 /pmc/articles/PMC4529689/ /pubmed/26253168 http://dx.doi.org/10.1186/s12906-015-0781-6 Text en © Qin et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Qin, Qingguang Mo, Qian Liu, Kun He, Xun Gao, Xinyan Zhu, Bing Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
title | Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
title_full | Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
title_fullStr | Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
title_full_unstemmed | Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
title_short | Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
title_sort | acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529689/ https://www.ncbi.nlm.nih.gov/pubmed/26253168 http://dx.doi.org/10.1186/s12906-015-0781-6 |
work_keys_str_mv | AT qinqingguang acupunctureathomotopicacupointsexertsdualeffectsonbladdermotilityinanesthetizedrats AT moqian acupunctureathomotopicacupointsexertsdualeffectsonbladdermotilityinanesthetizedrats AT liukun acupunctureathomotopicacupointsexertsdualeffectsonbladdermotilityinanesthetizedrats AT hexun acupunctureathomotopicacupointsexertsdualeffectsonbladdermotilityinanesthetizedrats AT gaoxinyan acupunctureathomotopicacupointsexertsdualeffectsonbladdermotilityinanesthetizedrats AT zhubing acupunctureathomotopicacupointsexertsdualeffectsonbladdermotilityinanesthetizedrats |