Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn’s disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact

INTRODUCTION: Crohn’s disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety and possible efficacy of mesenchymal stem cells (MSCs) as a new therapeutic t...

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Detalles Bibliográficos
Autores principales: Ciccocioppo, Rachele, Cangemi, Giuseppina C., Kruzliak, Peter, Gallia, Alessandra, Betti, Elena, Badulli, Carla, Martinetti, Miryam, Cervio, Marila, Pecci, Alessandro, Bozzi, Valeria, Dionigi, Paolo, Visai, Livia, Gurrado, Antonella, Alvisi, Costanza, Picone, Cristina, Monti, Manuela, Bernardo, Maria E., Gobbi, Paolo, Corazza, Gino R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529692/
https://www.ncbi.nlm.nih.gov/pubmed/26206376
http://dx.doi.org/10.1186/s13287-015-0122-1

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