Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression

To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for t...

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Autores principales: Kizilay Mancini, Ozge, Shum-Tim, Dominique, Stochaj, Ursula, Correa, José A., Colmegna, Inés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529693/
https://www.ncbi.nlm.nih.gov/pubmed/26253429
http://dx.doi.org/10.1186/s13287-015-0127-9
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author Kizilay Mancini, Ozge
Shum-Tim, Dominique
Stochaj, Ursula
Correa, José A.
Colmegna, Inés
author_facet Kizilay Mancini, Ozge
Shum-Tim, Dominique
Stochaj, Ursula
Correa, José A.
Colmegna, Inés
author_sort Kizilay Mancini, Ozge
collection PubMed
description To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13287-015-0127-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-45296932015-08-09 Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression Kizilay Mancini, Ozge Shum-Tim, Dominique Stochaj, Ursula Correa, José A. Colmegna, Inés Stem Cell Res Ther Short Report To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13287-015-0127-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-08-08 /pmc/articles/PMC4529693/ /pubmed/26253429 http://dx.doi.org/10.1186/s13287-015-0127-9 Text en © Kizilay Mancini et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Kizilay Mancini, Ozge
Shum-Tim, Dominique
Stochaj, Ursula
Correa, José A.
Colmegna, Inés
Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
title Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
title_full Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
title_fullStr Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
title_full_unstemmed Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
title_short Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
title_sort age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated t-cell suppression
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529693/
https://www.ncbi.nlm.nih.gov/pubmed/26253429
http://dx.doi.org/10.1186/s13287-015-0127-9
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