Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

BACKGROUND: A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruvate derived biochemicals. However, it cannot grow on glucose as the sole car...

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Detalles Bibliográficos
Autores principales: Zhang, Yiming, Liu, Guodong, Engqvist, Martin K M, Krivoruchko, Anastasia, Hallström, Björn M, Chen, Yun, Siewers, Verena, Nielsen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529725/
https://www.ncbi.nlm.nih.gov/pubmed/26253003
http://dx.doi.org/10.1186/s12934-015-0305-6

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