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Splicing Regulators and Their Roles in Cancer Biology and Therapy

Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cel...

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Autores principales: da Silva, Maria Roméria, Moreira, Gabriela Alves, Gonçalves da Silva, Ronni Anderson, de Almeida Alves Barbosa, Éverton, Pais Siqueira, Raoni, Teixera, Róbson Ricardo, Almeida, Márcia Rogéria, Silva Júnior, Abelardo, Fietto, Juliana Lopes Rangel, Bressan, Gustavo Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529883/
https://www.ncbi.nlm.nih.gov/pubmed/26273588
http://dx.doi.org/10.1155/2015/150514
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author da Silva, Maria Roméria
Moreira, Gabriela Alves
Gonçalves da Silva, Ronni Anderson
de Almeida Alves Barbosa, Éverton
Pais Siqueira, Raoni
Teixera, Róbson Ricardo
Almeida, Márcia Rogéria
Silva Júnior, Abelardo
Fietto, Juliana Lopes Rangel
Bressan, Gustavo Costa
author_facet da Silva, Maria Roméria
Moreira, Gabriela Alves
Gonçalves da Silva, Ronni Anderson
de Almeida Alves Barbosa, Éverton
Pais Siqueira, Raoni
Teixera, Róbson Ricardo
Almeida, Márcia Rogéria
Silva Júnior, Abelardo
Fietto, Juliana Lopes Rangel
Bressan, Gustavo Costa
author_sort da Silva, Maria Roméria
collection PubMed
description Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.
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spelling pubmed-45298832015-08-13 Splicing Regulators and Their Roles in Cancer Biology and Therapy da Silva, Maria Roméria Moreira, Gabriela Alves Gonçalves da Silva, Ronni Anderson de Almeida Alves Barbosa, Éverton Pais Siqueira, Raoni Teixera, Róbson Ricardo Almeida, Márcia Rogéria Silva Júnior, Abelardo Fietto, Juliana Lopes Rangel Bressan, Gustavo Costa Biomed Res Int Review Article Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed. Hindawi Publishing Corporation 2015 2015-07-26 /pmc/articles/PMC4529883/ /pubmed/26273588 http://dx.doi.org/10.1155/2015/150514 Text en Copyright © 2015 Maria Roméria da Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
da Silva, Maria Roméria
Moreira, Gabriela Alves
Gonçalves da Silva, Ronni Anderson
de Almeida Alves Barbosa, Éverton
Pais Siqueira, Raoni
Teixera, Róbson Ricardo
Almeida, Márcia Rogéria
Silva Júnior, Abelardo
Fietto, Juliana Lopes Rangel
Bressan, Gustavo Costa
Splicing Regulators and Their Roles in Cancer Biology and Therapy
title Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_full Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_fullStr Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_full_unstemmed Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_short Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_sort splicing regulators and their roles in cancer biology and therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529883/
https://www.ncbi.nlm.nih.gov/pubmed/26273588
http://dx.doi.org/10.1155/2015/150514
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