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Splicing Regulators and Their Roles in Cancer Biology and Therapy
Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cel...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529883/ https://www.ncbi.nlm.nih.gov/pubmed/26273588 http://dx.doi.org/10.1155/2015/150514 |
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author | da Silva, Maria Roméria Moreira, Gabriela Alves Gonçalves da Silva, Ronni Anderson de Almeida Alves Barbosa, Éverton Pais Siqueira, Raoni Teixera, Róbson Ricardo Almeida, Márcia Rogéria Silva Júnior, Abelardo Fietto, Juliana Lopes Rangel Bressan, Gustavo Costa |
author_facet | da Silva, Maria Roméria Moreira, Gabriela Alves Gonçalves da Silva, Ronni Anderson de Almeida Alves Barbosa, Éverton Pais Siqueira, Raoni Teixera, Róbson Ricardo Almeida, Márcia Rogéria Silva Júnior, Abelardo Fietto, Juliana Lopes Rangel Bressan, Gustavo Costa |
author_sort | da Silva, Maria Roméria |
collection | PubMed |
description | Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed. |
format | Online Article Text |
id | pubmed-4529883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45298832015-08-13 Splicing Regulators and Their Roles in Cancer Biology and Therapy da Silva, Maria Roméria Moreira, Gabriela Alves Gonçalves da Silva, Ronni Anderson de Almeida Alves Barbosa, Éverton Pais Siqueira, Raoni Teixera, Róbson Ricardo Almeida, Márcia Rogéria Silva Júnior, Abelardo Fietto, Juliana Lopes Rangel Bressan, Gustavo Costa Biomed Res Int Review Article Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed. Hindawi Publishing Corporation 2015 2015-07-26 /pmc/articles/PMC4529883/ /pubmed/26273588 http://dx.doi.org/10.1155/2015/150514 Text en Copyright © 2015 Maria Roméria da Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article da Silva, Maria Roméria Moreira, Gabriela Alves Gonçalves da Silva, Ronni Anderson de Almeida Alves Barbosa, Éverton Pais Siqueira, Raoni Teixera, Róbson Ricardo Almeida, Márcia Rogéria Silva Júnior, Abelardo Fietto, Juliana Lopes Rangel Bressan, Gustavo Costa Splicing Regulators and Their Roles in Cancer Biology and Therapy |
title | Splicing Regulators and Their Roles in Cancer Biology and Therapy |
title_full | Splicing Regulators and Their Roles in Cancer Biology and Therapy |
title_fullStr | Splicing Regulators and Their Roles in Cancer Biology and Therapy |
title_full_unstemmed | Splicing Regulators and Their Roles in Cancer Biology and Therapy |
title_short | Splicing Regulators and Their Roles in Cancer Biology and Therapy |
title_sort | splicing regulators and their roles in cancer biology and therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529883/ https://www.ncbi.nlm.nih.gov/pubmed/26273588 http://dx.doi.org/10.1155/2015/150514 |
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