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Research Progress on Regulatory T Cells in Acute Kidney Injury

Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate...

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Detalles Bibliográficos
Autores principales: Wang, Yamei, Tao, Yuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529954/
https://www.ncbi.nlm.nih.gov/pubmed/26273681
http://dx.doi.org/10.1155/2015/174164
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author Wang, Yamei
Tao, Yuhong
author_facet Wang, Yamei
Tao, Yuhong
author_sort Wang, Yamei
collection PubMed
description Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI.
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spelling pubmed-45299542015-08-13 Research Progress on Regulatory T Cells in Acute Kidney Injury Wang, Yamei Tao, Yuhong J Immunol Res Review Article Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI. Hindawi Publishing Corporation 2015 2015-07-26 /pmc/articles/PMC4529954/ /pubmed/26273681 http://dx.doi.org/10.1155/2015/174164 Text en Copyright © 2015 Y. Wang and Y. Tao. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Yamei
Tao, Yuhong
Research Progress on Regulatory T Cells in Acute Kidney Injury
title Research Progress on Regulatory T Cells in Acute Kidney Injury
title_full Research Progress on Regulatory T Cells in Acute Kidney Injury
title_fullStr Research Progress on Regulatory T Cells in Acute Kidney Injury
title_full_unstemmed Research Progress on Regulatory T Cells in Acute Kidney Injury
title_short Research Progress on Regulatory T Cells in Acute Kidney Injury
title_sort research progress on regulatory t cells in acute kidney injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529954/
https://www.ncbi.nlm.nih.gov/pubmed/26273681
http://dx.doi.org/10.1155/2015/174164
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