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Research Progress on Regulatory T Cells in Acute Kidney Injury
Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529954/ https://www.ncbi.nlm.nih.gov/pubmed/26273681 http://dx.doi.org/10.1155/2015/174164 |
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author | Wang, Yamei Tao, Yuhong |
author_facet | Wang, Yamei Tao, Yuhong |
author_sort | Wang, Yamei |
collection | PubMed |
description | Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI. |
format | Online Article Text |
id | pubmed-4529954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45299542015-08-13 Research Progress on Regulatory T Cells in Acute Kidney Injury Wang, Yamei Tao, Yuhong J Immunol Res Review Article Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI. Hindawi Publishing Corporation 2015 2015-07-26 /pmc/articles/PMC4529954/ /pubmed/26273681 http://dx.doi.org/10.1155/2015/174164 Text en Copyright © 2015 Y. Wang and Y. Tao. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Yamei Tao, Yuhong Research Progress on Regulatory T Cells in Acute Kidney Injury |
title | Research Progress on Regulatory T Cells in Acute Kidney Injury |
title_full | Research Progress on Regulatory T Cells in Acute Kidney Injury |
title_fullStr | Research Progress on Regulatory T Cells in Acute Kidney Injury |
title_full_unstemmed | Research Progress on Regulatory T Cells in Acute Kidney Injury |
title_short | Research Progress on Regulatory T Cells in Acute Kidney Injury |
title_sort | research progress on regulatory t cells in acute kidney injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529954/ https://www.ncbi.nlm.nih.gov/pubmed/26273681 http://dx.doi.org/10.1155/2015/174164 |
work_keys_str_mv | AT wangyamei researchprogressonregulatorytcellsinacutekidneyinjury AT taoyuhong researchprogressonregulatorytcellsinacutekidneyinjury |