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Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic targets in cancer and other diseases. Current screening strategies target CRISPR-induced mutations to the 5’ exons of candidate genes(1–5), but this approach often produces in-frame variants that retain functionali...

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Detalles Bibliográficos
Autores principales:	Shi, Junwei, Wang, Eric, Milazzo, Joseph P., Wang, Zhihua, Kinney, Justin B., Vakoc, Christopher R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529991/ https://www.ncbi.nlm.nih.gov/pubmed/25961408 http://dx.doi.org/10.1038/nbt.3235

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