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Managing Side Effects of Vemurafenib Therapy for Advanced Melanoma
Somatic point mutations in the BRAF gene have been found in approximately 50% of melanomas. BRAF(V600E), the most common mutation, results in the constitutive activation of BRAF(V600E) kinase, sustaining MAPK signaling and perpetuating cell growth. This groundbreaking discovery led to the clinical d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Harborside Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530112/ https://www.ncbi.nlm.nih.gov/pubmed/26328215 |