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Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation
Reactive oxygen species (ROS) have long been considered as pathological agents inducing apoptosis under adverse culture conditions. However, recent findings have challenged this dogma and physiological levels of ROS are now considered as secondary messengers, mediating numerous cellular functions in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530287/ https://www.ncbi.nlm.nih.gov/pubmed/26273419 http://dx.doi.org/10.1155/2015/105135 |
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author | Sart, Sébastien Song, Liqing Li, Yan |
author_facet | Sart, Sébastien Song, Liqing Li, Yan |
author_sort | Sart, Sébastien |
collection | PubMed |
description | Reactive oxygen species (ROS) have long been considered as pathological agents inducing apoptosis under adverse culture conditions. However, recent findings have challenged this dogma and physiological levels of ROS are now considered as secondary messengers, mediating numerous cellular functions in stem cells. Stem cells represent important tools for tissue engineering, drug screening, and disease modeling. However, the safe use of stem cells for clinical applications still requires culture improvements to obtain functional cells. With the examples of mesenchymal stem cells (MSCs) and pluripotent stem cells (PSCs), this review investigates the roles of ROS in the maintenance of self-renewal, proliferation, and differentiation of stem cells. In addition, this work highlights that the tight control of stem cell microenvironment, including cell organization, and metabolic and mechanical environments, may be an effective approach to regulate endogenous ROS generation. Taken together, this paper indicates the need for better quantification of ROS towards the accurate control of stem cell fate. |
format | Online Article Text |
id | pubmed-4530287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45302872015-08-13 Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation Sart, Sébastien Song, Liqing Li, Yan Oxid Med Cell Longev Review Article Reactive oxygen species (ROS) have long been considered as pathological agents inducing apoptosis under adverse culture conditions. However, recent findings have challenged this dogma and physiological levels of ROS are now considered as secondary messengers, mediating numerous cellular functions in stem cells. Stem cells represent important tools for tissue engineering, drug screening, and disease modeling. However, the safe use of stem cells for clinical applications still requires culture improvements to obtain functional cells. With the examples of mesenchymal stem cells (MSCs) and pluripotent stem cells (PSCs), this review investigates the roles of ROS in the maintenance of self-renewal, proliferation, and differentiation of stem cells. In addition, this work highlights that the tight control of stem cell microenvironment, including cell organization, and metabolic and mechanical environments, may be an effective approach to regulate endogenous ROS generation. Taken together, this paper indicates the need for better quantification of ROS towards the accurate control of stem cell fate. Hindawi Publishing Corporation 2015 2015-07-27 /pmc/articles/PMC4530287/ /pubmed/26273419 http://dx.doi.org/10.1155/2015/105135 Text en Copyright © 2015 Sébastien Sart et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sart, Sébastien Song, Liqing Li, Yan Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation |
title | Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation |
title_full | Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation |
title_fullStr | Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation |
title_full_unstemmed | Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation |
title_short | Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation |
title_sort | controlling redox status for stem cell survival, expansion, and differentiation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530287/ https://www.ncbi.nlm.nih.gov/pubmed/26273419 http://dx.doi.org/10.1155/2015/105135 |
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