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Feeding regulates sex pheromone attraction and courtship in Drosophila females
In Drosophila melanogaster, gender-specific behavioural responses to the male-produced sex pheromone cis-vaccenyl acetate (cVA) rely on sexually dimorphic, third-order neural circuits. We show that nutritional state in female flies modulates cVA perception in first-order olfactory neurons. Starvatio...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530334/ https://www.ncbi.nlm.nih.gov/pubmed/26255707 http://dx.doi.org/10.1038/srep13132 |
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author | Lebreton, Sébastien Trona, Federica Borrero-Echeverry, Felipe Bilz, Florian Grabe, Veit Becher, Paul G. Carlsson, Mikael A. Nässel, Dick R. Hansson, Bill S. Sachse, Silke Witzgall, Peter |
author_facet | Lebreton, Sébastien Trona, Federica Borrero-Echeverry, Felipe Bilz, Florian Grabe, Veit Becher, Paul G. Carlsson, Mikael A. Nässel, Dick R. Hansson, Bill S. Sachse, Silke Witzgall, Peter |
author_sort | Lebreton, Sébastien |
collection | PubMed |
description | In Drosophila melanogaster, gender-specific behavioural responses to the male-produced sex pheromone cis-vaccenyl acetate (cVA) rely on sexually dimorphic, third-order neural circuits. We show that nutritional state in female flies modulates cVA perception in first-order olfactory neurons. Starvation increases, and feeding reduces attraction to food odour, in both sexes. Adding cVA to food odour, however, maintains attraction in fed females, while it has no effect in males. Upregulation of sensitivity and behavioural responsiveness to cVA in fed females is paralleled by a strong increase in receptivity to male courtship. Functional imaging of the antennal lobe (AL), the olfactory centre in the insect brain, shows that olfactory input to DA1 and VM2 glomeruli is also modulated by starvation. Knocking down insulin receptors in neurons converging onto the DA1 glomerulus suggests that insulin-signalling partly controls pheromone perception in the AL, and adjusts cVA attraction according to nutritional state and sexual receptivity in Drosophila females. |
format | Online Article Text |
id | pubmed-4530334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45303342015-08-11 Feeding regulates sex pheromone attraction and courtship in Drosophila females Lebreton, Sébastien Trona, Federica Borrero-Echeverry, Felipe Bilz, Florian Grabe, Veit Becher, Paul G. Carlsson, Mikael A. Nässel, Dick R. Hansson, Bill S. Sachse, Silke Witzgall, Peter Sci Rep Article In Drosophila melanogaster, gender-specific behavioural responses to the male-produced sex pheromone cis-vaccenyl acetate (cVA) rely on sexually dimorphic, third-order neural circuits. We show that nutritional state in female flies modulates cVA perception in first-order olfactory neurons. Starvation increases, and feeding reduces attraction to food odour, in both sexes. Adding cVA to food odour, however, maintains attraction in fed females, while it has no effect in males. Upregulation of sensitivity and behavioural responsiveness to cVA in fed females is paralleled by a strong increase in receptivity to male courtship. Functional imaging of the antennal lobe (AL), the olfactory centre in the insect brain, shows that olfactory input to DA1 and VM2 glomeruli is also modulated by starvation. Knocking down insulin receptors in neurons converging onto the DA1 glomerulus suggests that insulin-signalling partly controls pheromone perception in the AL, and adjusts cVA attraction according to nutritional state and sexual receptivity in Drosophila females. Nature Publishing Group 2015-08-10 /pmc/articles/PMC4530334/ /pubmed/26255707 http://dx.doi.org/10.1038/srep13132 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lebreton, Sébastien Trona, Federica Borrero-Echeverry, Felipe Bilz, Florian Grabe, Veit Becher, Paul G. Carlsson, Mikael A. Nässel, Dick R. Hansson, Bill S. Sachse, Silke Witzgall, Peter Feeding regulates sex pheromone attraction and courtship in Drosophila females |
title | Feeding regulates sex pheromone attraction and courtship in Drosophila females |
title_full | Feeding regulates sex pheromone attraction and courtship in Drosophila females |
title_fullStr | Feeding regulates sex pheromone attraction and courtship in Drosophila females |
title_full_unstemmed | Feeding regulates sex pheromone attraction and courtship in Drosophila females |
title_short | Feeding regulates sex pheromone attraction and courtship in Drosophila females |
title_sort | feeding regulates sex pheromone attraction and courtship in drosophila females |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530334/ https://www.ncbi.nlm.nih.gov/pubmed/26255707 http://dx.doi.org/10.1038/srep13132 |
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