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High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil

Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects...

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Autores principales: Sales, Stephanie Hael, Matta, Sandra da, Silva, Daniela Cardeal da, Assone, Tatiane Assone, Fonseca, Luiz Augusto M., Duarte, Alberto J. S., Casseb, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530336/
https://www.ncbi.nlm.nih.gov/pubmed/26257370
http://dx.doi.org/10.1038/srep12990
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author Sales, Stephanie Hael
Matta, Sandra da
Silva, Daniela Cardeal da
Assone, Tatiane Assone
Fonseca, Luiz Augusto M.
Duarte, Alberto J. S.
Casseb, Jorge
author_facet Sales, Stephanie Hael
Matta, Sandra da
Silva, Daniela Cardeal da
Assone, Tatiane Assone
Fonseca, Luiz Augusto M.
Duarte, Alberto J. S.
Casseb, Jorge
author_sort Sales, Stephanie Hael
collection PubMed
description Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make their nutritional diagnoses, including their vitamin D blood levels, and to estimate their consumption of vitamin D. The study included 98 HIV-1-infected subjects, followed at University of São Paulo Medical School - HC-FMUSP. We performed a nutritional evaluation, along with the determination of patients’ serum 25-hydroxyvitamin D and calcium concentration, biochemical analyses, and an anthropometric assessment. In the medical interview a 24-hour food recall was used (R24) to estimate daily calorie intake, macronutrients, calcium, and vitamin D. A high level of vitamin D deficiency was observed in our patients: 83.4% of them had levels below 30 ng/ml; they also presented an increased risk of cardiovascular disease, along with a high consumption of dietary fat. Factors related to the virus itself and to the use of antiretroviral drugs may have contributed for the low vitamin D levels seen in our HIV-1-infected patients.
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spelling pubmed-45303362015-08-11 High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil Sales, Stephanie Hael Matta, Sandra da Silva, Daniela Cardeal da Assone, Tatiane Assone Fonseca, Luiz Augusto M. Duarte, Alberto J. S. Casseb, Jorge Sci Rep Article Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make their nutritional diagnoses, including their vitamin D blood levels, and to estimate their consumption of vitamin D. The study included 98 HIV-1-infected subjects, followed at University of São Paulo Medical School - HC-FMUSP. We performed a nutritional evaluation, along with the determination of patients’ serum 25-hydroxyvitamin D and calcium concentration, biochemical analyses, and an anthropometric assessment. In the medical interview a 24-hour food recall was used (R24) to estimate daily calorie intake, macronutrients, calcium, and vitamin D. A high level of vitamin D deficiency was observed in our patients: 83.4% of them had levels below 30 ng/ml; they also presented an increased risk of cardiovascular disease, along with a high consumption of dietary fat. Factors related to the virus itself and to the use of antiretroviral drugs may have contributed for the low vitamin D levels seen in our HIV-1-infected patients. Nature Publishing Group 2015-08-10 /pmc/articles/PMC4530336/ /pubmed/26257370 http://dx.doi.org/10.1038/srep12990 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sales, Stephanie Hael
Matta, Sandra da
Silva, Daniela Cardeal da
Assone, Tatiane Assone
Fonseca, Luiz Augusto M.
Duarte, Alberto J. S.
Casseb, Jorge
High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
title High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
title_full High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
title_fullStr High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
title_full_unstemmed High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
title_short High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from São Paulo city, Brazil
title_sort high frequency of deficient consumption and low blood levels of 25-hydroxyvitamin d in hiv-1-infected adults from são paulo city, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530336/
https://www.ncbi.nlm.nih.gov/pubmed/26257370
http://dx.doi.org/10.1038/srep12990
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