Slow mitochondrial repair of 5′-AMP renders mtDNA susceptible to damage in APTX deficient cells

Aborted DNA ligation events in eukaryotic cells can generate 5′-adenylated (5′-AMP) DNA termini that can be removed from DNA by aprataxin (APTX). Mutations in APTX cause an inherited human disease syndrome characterized by early-onset progressive ataxia with ocular motor apraxia (AOA1). APTX is foun...

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Detalles Bibliográficos
Autores principales: Akbari, Mansour, Sykora, Peter, Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530458/
https://www.ncbi.nlm.nih.gov/pubmed/26256098
http://dx.doi.org/10.1038/srep12876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530458/
https://www.ncbi.nlm.nih.gov/pubmed/26256098
http://dx.doi.org/10.1038/srep12876

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