Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice

We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A...

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Detalles Bibliográficos
Autores principales: Kikuta, Satomi, Nakamura, Yukiyo, Yamamura, Yukio, Tamura, Atsushi, Homma, Noriyasu, Yanagawa, Yuchio, Tamura, Hajime, Kasahara, Jiro, Osanai, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530460/
https://www.ncbi.nlm.nih.gov/pubmed/26255701
http://dx.doi.org/10.1038/srep12800
Descripción
Sumario:We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.

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