Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice

We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A...

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Autores principales: Kikuta, Satomi, Nakamura, Yukiyo, Yamamura, Yukio, Tamura, Atsushi, Homma, Noriyasu, Yanagawa, Yuchio, Tamura, Hajime, Kasahara, Jiro, Osanai, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530460/
https://www.ncbi.nlm.nih.gov/pubmed/26255701
http://dx.doi.org/10.1038/srep12800
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author Kikuta, Satomi
Nakamura, Yukiyo
Yamamura, Yukio
Tamura, Atsushi
Homma, Noriyasu
Yanagawa, Yuchio
Tamura, Hajime
Kasahara, Jiro
Osanai, Makoto
author_facet Kikuta, Satomi
Nakamura, Yukiyo
Yamamura, Yukio
Tamura, Atsushi
Homma, Noriyasu
Yanagawa, Yuchio
Tamura, Hajime
Kasahara, Jiro
Osanai, Makoto
author_sort Kikuta, Satomi
collection PubMed
description We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
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spelling pubmed-45304602015-08-11 Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice Kikuta, Satomi Nakamura, Yukiyo Yamamura, Yukio Tamura, Atsushi Homma, Noriyasu Yanagawa, Yuchio Tamura, Hajime Kasahara, Jiro Osanai, Makoto Sci Rep Article We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms. Nature Publishing Group 2015-08-10 /pmc/articles/PMC4530460/ /pubmed/26255701 http://dx.doi.org/10.1038/srep12800 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kikuta, Satomi
Nakamura, Yukiyo
Yamamura, Yukio
Tamura, Atsushi
Homma, Noriyasu
Yanagawa, Yuchio
Tamura, Hajime
Kasahara, Jiro
Osanai, Makoto
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice
title Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice
title_full Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice
title_fullStr Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice
title_full_unstemmed Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice
title_short Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson’s disease in mice
title_sort quantitative activation-induced manganese-enhanced mri reveals severity of parkinson’s disease in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530460/
https://www.ncbi.nlm.nih.gov/pubmed/26255701
http://dx.doi.org/10.1038/srep12800
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