Cargando…

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Early MAT formation in mice is conserved, whereas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scheller, Erica L., Doucette, Casey R., Learman, Brian S., Cawthorn, William P., Khandaker, Shaima, Schell, Benjamin, Wu, Brent, Ding, Shi-Ying, Bredella, Miriam A., Fazeli, Pouneh K., Khoury, Basma, Jepsen, Karl J., Pilch, Paul F., Klibanski, Anne, Rosen, Clifford J., MacDougald, Ormond A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530473/ https://www.ncbi.nlm.nih.gov/pubmed/26245716 http://dx.doi.org/10.1038/ncomms8808

Ejemplares similares

Corrigendum: Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues
por: Scheller, Erica L., et al.
Publicado: (2016)

Inside out: Bone marrow adipose tissue as a source of circulating adiponectin
por: Scheller, Erica L., et al.
Publicado: (2016)

Constitutive bone marrow adipocytes suppress local bone formation
por: Li, Ziru, et al.
Publicado: (2022)

The dynamics of human bone marrow adipose tissue in response to feeding and fasting
por: Fazeli, Pouneh K., et al.
Publicado: (2021)

ODP053 Serum Free Cortisol and Free Cortisol-to-Cortisone Ratio Increase After 10 Days of Overfeeding and After 10 Days of Fasting
por: Colling, Caitlin, et al.
Publicado: (2022)

Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass
por: Simon, Becky R., et al.
Publicado: (2014)

SUN-350 Bone Marrow Adipose Tissue Is Associated with Fracture Prevalence in Anorexia Nervosa
por: Dang, Tran, et al.
Publicado: (2020)

Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction
por: Bagchi, Devika P., et al.
Publicado: (2020)

Increased Circulating Adiponectin in Response to Thiazolidinediones: Investigating the Role of Bone Marrow Adipose Tissue
por: Sulston, Richard J., et al.
Publicado: (2016)

Signaling Pathway Puts the Break on Fat Cell Formation
por: MacDougald, Ormond A.
Publicado: (2001)

Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells
por: Bagchi, Devika P., et al.
Publicado: (2020)

SAT650 Catecholamine-independent Neural Pathways Drive The Rapid Catabolism Of Metabolically Inert Fat
por: Zhang, Xiao, et al.
Publicado: (2023)

Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling
por: Craft, Clarissa S., et al.
Publicado: (2019)

Modulation of neural fMRI responses to visual food cues by overeating and fasting interventions: A preliminary study
por: Kerem, Liya, et al.
Publicado: (2020)

Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element
por: Lewis, Kenneth T., et al.
Publicado: (2022)

Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion
por: Mori, Hiroyuki, et al.
Publicado: (2016)

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits
por: Li, Ziru, et al.
Publicado: (2022)

SRA Regulates Adipogenesis by Modulating p38/JNK Phosphorylation and Stimulating Insulin Receptor Gene Expression and Downstream Signaling
por: Liu, Shannon, et al.
Publicado: (2014)

The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
por: Mori, Hiroyuki, et al.
Publicado: (2021)

386 A novel truncating variant of EBF2 disrupts human adipocyte differentiation in lipodystrophy syndromes: an example of a discovery from a clinical translational pipeline
por: Foss-Freitas, Maria C., et al.
Publicado: (2023)

FRI018 A Novel Truncating Variant Of EBF2 Disrupts Human Adipocyte Differentiation In Lipodystrophy Syndromes: An Example Of A Discovery From A Clinical Translational Pipeline
por: Foss de Freitas, Maria Cristina, et al.
Publicado: (2023)

Multiple Roles for the Non-Coding RNA SRA in Regulation of Adipogenesis and Insulin Sensitivity
por: Xu, Bin, et al.
Publicado: (2010)

OR03-6 Tibial and Radial Bone Structure as Assessed by HRpQCT May Explain Differences in Peripheral Skeletal Integrity and Fracture Risk Across the Weight Spectrum That Cannot Be Explained by Areal BMD Alone
por: Schorr, Melanie, et al.
Publicado: (2019)

Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity
por: Ma, Xiaoya, et al.
Publicado: (2017)

PSUN138 Demonstration of Progressive Beta-Cell Failure in Familial Partial Lipodystrophy
por: De Freitas, Maria Foss, et al.
Publicado: (2022)

Changes in Skeletal Integrity and Marrow Adiposity during High-Fat Diet and after Weight Loss
por: Scheller, Erica L., et al.
Publicado: (2016)

Adipose METTL14‐Elicited N(6)‐Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis
por: Kang, Qianqian, et al.
Publicado: (2023)

Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2
por: Corsa, Callie A.S., et al.
Publicado: (2021)

Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a
por: Chen, Yii-Shyuan, et al.
Publicado: (2016)

SAT-622 Heterogeneity of Familial Partial Lipodystrophy Type 2 from a Genotype-Phenotype Perspective
por: de Freitas, Maria Cristina Foss, et al.
Publicado: (2020)

Body Composition And Bone Mineral Differences According to Lamin A (LMNA) Genotype in Familial Partial Lipodystrophy Type 2
por: de Freitas, Maria Cristina Foss, et al.
Publicado: (2021)

SUN-273 A Rare Case of IgG4-Related Hypophysitis
por: Ravindra, Sindhura, et al.
Publicado: (2020)

Estrogen for the Treatment of Low Bone Mineral Density in Anorexia Nervosa
por: Thavaraputta, Subhanudh, et al.
Publicado: (2022)

Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring
por: Hafner, Hannah, et al.
Publicado: (2019)

Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls
por: Savgan-Gurol, Eray, et al.
Publicado: (2010)

Editorial: Bone Marrow Adipose Tissue: Formation, Function, and Impact on Health and Disease
por: Cawthorn, William P., et al.
Publicado: (2017)

Bone Marrow Adipocytes: A Link between Obesity and Bone Cancer
por: Reagan, Michaela R., et al.
Publicado: (2021)

Standardised Nomenclature, Abbreviations, and Units for the Study of Bone Marrow Adiposity: Report of the Nomenclature Working Group of the International Bone Marrow Adiposity Society
por: Bravenboer, Nathalie, et al.
Publicado: (2020)

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis
por: You, Zongbing, et al.
Publicado: (2002)

Correction: Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis
por: You, Zongbing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t7nd3cr9usistlf4pkdlt129m6