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Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease

Dendritic cells are potent antigen‐capture and antigen‐presenting cells that play a key role in the initiation and regulation of the adaptive immune response. This process of immune homeostasis, as maintained by dendritic cells, is susceptible to dysregulation by certain pathogens during chronic inf...

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Detalles Bibliográficos
Autores principales: El‐Awady, Ahmed R., Arce, Roger M., Cutler, Christopher W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530502/
https://www.ncbi.nlm.nih.gov/pubmed/26252408
http://dx.doi.org/10.1111/prd.12096
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author El‐Awady, Ahmed R.
Arce, Roger M.
Cutler, Christopher W.
author_facet El‐Awady, Ahmed R.
Arce, Roger M.
Cutler, Christopher W.
author_sort El‐Awady, Ahmed R.
collection PubMed
description Dendritic cells are potent antigen‐capture and antigen‐presenting cells that play a key role in the initiation and regulation of the adaptive immune response. This process of immune homeostasis, as maintained by dendritic cells, is susceptible to dysregulation by certain pathogens during chronic infections. Such dysregulation may lead to disease perpetuation with potentially severe systemic consequences. Here we discuss in detail how intracellular pathogens exploit dendritic cells and escape degradation by altering or evading autophagy. This novel mechanism explains, in part, the chronic, persistent nature observed in several immuno‐inflammatory diseases, including periodontal disease. We also propose a hypothetical model of the plausible role of autophagy in the context of periodontal disease. Promotion of autophagy may open new therapeutic strategies in the search of a ‘cure’ for periodontal disease in humans.
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spelling pubmed-45305022016-10-01 Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease El‐Awady, Ahmed R. Arce, Roger M. Cutler, Christopher W. Periodontol 2000 Review Articles Dendritic cells are potent antigen‐capture and antigen‐presenting cells that play a key role in the initiation and regulation of the adaptive immune response. This process of immune homeostasis, as maintained by dendritic cells, is susceptible to dysregulation by certain pathogens during chronic infections. Such dysregulation may lead to disease perpetuation with potentially severe systemic consequences. Here we discuss in detail how intracellular pathogens exploit dendritic cells and escape degradation by altering or evading autophagy. This novel mechanism explains, in part, the chronic, persistent nature observed in several immuno‐inflammatory diseases, including periodontal disease. We also propose a hypothetical model of the plausible role of autophagy in the context of periodontal disease. Promotion of autophagy may open new therapeutic strategies in the search of a ‘cure’ for periodontal disease in humans. John Wiley and Sons Inc. 2015-08-07 2015-10 /pmc/articles/PMC4530502/ /pubmed/26252408 http://dx.doi.org/10.1111/prd.12096 Text en © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
spellingShingle Review Articles
El‐Awady, Ahmed R.
Arce, Roger M.
Cutler, Christopher W.
Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
title Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
title_full Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
title_fullStr Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
title_full_unstemmed Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
title_short Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
title_sort dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530502/
https://www.ncbi.nlm.nih.gov/pubmed/26252408
http://dx.doi.org/10.1111/prd.12096
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