Mechanisms of hypothermia-induced cell protection in the brain

Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia re...

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Detalles Bibliográficos
Autores principales: Schmitt, Katharina Rose Luise, Tong, Giang, Berger, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530563/
https://www.ncbi.nlm.nih.gov/pubmed/26567101
http://dx.doi.org/10.1186/s40348-014-0007-x
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author Schmitt, Katharina Rose Luise
Tong, Giang
Berger, Felix
author_facet Schmitt, Katharina Rose Luise
Tong, Giang
Berger, Felix
author_sort Schmitt, Katharina Rose Luise
collection PubMed
description Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention.
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spelling pubmed-45305632015-08-19 Mechanisms of hypothermia-induced cell protection in the brain Schmitt, Katharina Rose Luise Tong, Giang Berger, Felix Mol Cell Pediatr Review Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention. Springer Berlin Heidelberg 2014-12-01 /pmc/articles/PMC4530563/ /pubmed/26567101 http://dx.doi.org/10.1186/s40348-014-0007-x Text en © Schmitt et al; licensee Springer. 2014 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Review
Schmitt, Katharina Rose Luise
Tong, Giang
Berger, Felix
Mechanisms of hypothermia-induced cell protection in the brain
title Mechanisms of hypothermia-induced cell protection in the brain
title_full Mechanisms of hypothermia-induced cell protection in the brain
title_fullStr Mechanisms of hypothermia-induced cell protection in the brain
title_full_unstemmed Mechanisms of hypothermia-induced cell protection in the brain
title_short Mechanisms of hypothermia-induced cell protection in the brain
title_sort mechanisms of hypothermia-induced cell protection in the brain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530563/
https://www.ncbi.nlm.nih.gov/pubmed/26567101
http://dx.doi.org/10.1186/s40348-014-0007-x
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