Are microRNAs suitable biomarkers of immunity to tuberculosis?

BACKGROUND: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major import...

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Detalles Bibliográficos
Autores principales: Ueberberg, Bianca, Kohns, Malte, Mayatepek, Ertan, Jacobsen, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530568/
https://www.ncbi.nlm.nih.gov/pubmed/26567102
http://dx.doi.org/10.1186/s40348-014-0008-9
Descripción
Sumario:BACKGROUND: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance. CONCLUSIONS: This review summarizes recent surrogate tissue studies for identification of miRNA biomarker candidates in human tuberculosis with a special focus on reproducibility and conformance. In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls.

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