Are microRNAs suitable biomarkers of immunity to tuberculosis?

BACKGROUND: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major import...

Descripción completa

Detalles Bibliográficos
Autores principales: Ueberberg, Bianca, Kohns, Malte, Mayatepek, Ertan, Jacobsen, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530568/
https://www.ncbi.nlm.nih.gov/pubmed/26567102
http://dx.doi.org/10.1186/s40348-014-0008-9
_version_ 1782384919531487232
author Ueberberg, Bianca
Kohns, Malte
Mayatepek, Ertan
Jacobsen, Marc
author_facet Ueberberg, Bianca
Kohns, Malte
Mayatepek, Ertan
Jacobsen, Marc
author_sort Ueberberg, Bianca
collection PubMed
description BACKGROUND: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance. CONCLUSIONS: This review summarizes recent surrogate tissue studies for identification of miRNA biomarker candidates in human tuberculosis with a special focus on reproducibility and conformance. In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls.
format Online
Article
Text
id pubmed-4530568
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-45305682015-08-19 Are microRNAs suitable biomarkers of immunity to tuberculosis? Ueberberg, Bianca Kohns, Malte Mayatepek, Ertan Jacobsen, Marc Mol Cell Pediatr Mini Review BACKGROUND: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance. CONCLUSIONS: This review summarizes recent surrogate tissue studies for identification of miRNA biomarker candidates in human tuberculosis with a special focus on reproducibility and conformance. In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls. Springer Berlin Heidelberg 2014-10-03 /pmc/articles/PMC4530568/ /pubmed/26567102 http://dx.doi.org/10.1186/s40348-014-0008-9 Text en © Ueberberg et al. : licensee Springer 2014 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Mini Review
Ueberberg, Bianca
Kohns, Malte
Mayatepek, Ertan
Jacobsen, Marc
Are microRNAs suitable biomarkers of immunity to tuberculosis?
title Are microRNAs suitable biomarkers of immunity to tuberculosis?
title_full Are microRNAs suitable biomarkers of immunity to tuberculosis?
title_fullStr Are microRNAs suitable biomarkers of immunity to tuberculosis?
title_full_unstemmed Are microRNAs suitable biomarkers of immunity to tuberculosis?
title_short Are microRNAs suitable biomarkers of immunity to tuberculosis?
title_sort are micrornas suitable biomarkers of immunity to tuberculosis?
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530568/
https://www.ncbi.nlm.nih.gov/pubmed/26567102
http://dx.doi.org/10.1186/s40348-014-0008-9
work_keys_str_mv AT ueberbergbianca aremicrornassuitablebiomarkersofimmunitytotuberculosis
AT kohnsmalte aremicrornassuitablebiomarkersofimmunitytotuberculosis
AT mayatepekertan aremicrornassuitablebiomarkersofimmunitytotuberculosis
AT jacobsenmarc aremicrornassuitablebiomarkersofimmunitytotuberculosis

Ejemplares similares