The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases

Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as...

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Detalles Bibliográficos
Autores principales: Mack, Ines, Hector, Andreas, Ballbach, Marlene, Kohlhäufl, Julius, Fuchs, Katharina J, Weber, Alexander, Mall, Marcus A, Hartl, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530573/
https://www.ncbi.nlm.nih.gov/pubmed/26542293
http://dx.doi.org/10.1186/s40348-015-0014-6
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author Mack, Ines
Hector, Andreas
Ballbach, Marlene
Kohlhäufl, Julius
Fuchs, Katharina J
Weber, Alexander
Mall, Marcus A
Hartl, Dominik
author_facet Mack, Ines
Hector, Andreas
Ballbach, Marlene
Kohlhäufl, Julius
Fuchs, Katharina J
Weber, Alexander
Mall, Marcus A
Hartl, Dominik
author_sort Mack, Ines
collection PubMed
description Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as chitinase-like proteins that modulate immune responses. Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions. Here, we summarize and discuss the potential role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases.
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spelling pubmed-45305732015-08-19 The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases Mack, Ines Hector, Andreas Ballbach, Marlene Kohlhäufl, Julius Fuchs, Katharina J Weber, Alexander Mall, Marcus A Hartl, Dominik Mol Cell Pediatr Review Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as chitinase-like proteins that modulate immune responses. Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions. Here, we summarize and discuss the potential role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. Springer Berlin Heidelberg 2015-02-27 /pmc/articles/PMC4530573/ /pubmed/26542293 http://dx.doi.org/10.1186/s40348-015-0014-6 Text en © Mack et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Review
Mack, Ines
Hector, Andreas
Ballbach, Marlene
Kohlhäufl, Julius
Fuchs, Katharina J
Weber, Alexander
Mall, Marcus A
Hartl, Dominik
The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
title The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
title_full The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
title_fullStr The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
title_full_unstemmed The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
title_short The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
title_sort role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530573/
https://www.ncbi.nlm.nih.gov/pubmed/26542293
http://dx.doi.org/10.1186/s40348-015-0014-6
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