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Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh
Vibrio cholerae, the cause of cholera, induces both innate and adaptive immune responses in infected humans. Leptin is a hormone that plays a role in both metabolism and mediating immune responses. We characterized leptin levels in 11 children with cholera in Bangladesh, assessing leptin levels on d...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530742/ https://www.ncbi.nlm.nih.gov/pubmed/26055740 http://dx.doi.org/10.4269/ajtmh.15-0172 |
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author | Falkard, Brie Uddin, Taher Arifur Rahman, M. Franke, Molly F. Aktar, Amena Uddin, Muhammad Ikhtear Bhuiyan, Taufiqur Rahman Leung, Daniel T. Charles, Richelle C. Larocque, Regina C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. |
author_facet | Falkard, Brie Uddin, Taher Arifur Rahman, M. Franke, Molly F. Aktar, Amena Uddin, Muhammad Ikhtear Bhuiyan, Taufiqur Rahman Leung, Daniel T. Charles, Richelle C. Larocque, Regina C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. |
author_sort | Falkard, Brie |
collection | PubMed |
description | Vibrio cholerae, the cause of cholera, induces both innate and adaptive immune responses in infected humans. Leptin is a hormone that plays a role in both metabolism and mediating immune responses. We characterized leptin levels in 11 children with cholera in Bangladesh, assessing leptin levels on days 2, 7, 30, and 180 following cholera. We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence. We then assessed immune responses to V. cholerae antigens in 74 children with cholera, correlating these responses to plasma leptin levels on day 2 of illness. In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses. This finding appeared to be limited to children with better nutritional status. Interestingly, we found no association between leptin levels and antibody responses to V. cholerae lipopolysaccharide, a T cell–independent antigen. Our results suggest that leptin levels may be associated with cholera, including the development of immune responses to T cell–dependent antigens. |
format | Online Article Text |
id | pubmed-4530742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-45307422015-08-17 Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh Falkard, Brie Uddin, Taher Arifur Rahman, M. Franke, Molly F. Aktar, Amena Uddin, Muhammad Ikhtear Bhuiyan, Taufiqur Rahman Leung, Daniel T. Charles, Richelle C. Larocque, Regina C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. Am J Trop Med Hyg Articles Vibrio cholerae, the cause of cholera, induces both innate and adaptive immune responses in infected humans. Leptin is a hormone that plays a role in both metabolism and mediating immune responses. We characterized leptin levels in 11 children with cholera in Bangladesh, assessing leptin levels on days 2, 7, 30, and 180 following cholera. We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence. We then assessed immune responses to V. cholerae antigens in 74 children with cholera, correlating these responses to plasma leptin levels on day 2 of illness. In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses. This finding appeared to be limited to children with better nutritional status. Interestingly, we found no association between leptin levels and antibody responses to V. cholerae lipopolysaccharide, a T cell–independent antigen. Our results suggest that leptin levels may be associated with cholera, including the development of immune responses to T cell–dependent antigens. The American Society of Tropical Medicine and Hygiene 2015-08-05 /pmc/articles/PMC4530742/ /pubmed/26055740 http://dx.doi.org/10.4269/ajtmh.15-0172 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Articles Falkard, Brie Uddin, Taher Arifur Rahman, M. Franke, Molly F. Aktar, Amena Uddin, Muhammad Ikhtear Bhuiyan, Taufiqur Rahman Leung, Daniel T. Charles, Richelle C. Larocque, Regina C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh |
title | Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh |
title_full | Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh |
title_fullStr | Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh |
title_full_unstemmed | Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh |
title_short | Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh |
title_sort | plasma leptin levels in children hospitalized with cholera in bangladesh |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530742/ https://www.ncbi.nlm.nih.gov/pubmed/26055740 http://dx.doi.org/10.4269/ajtmh.15-0172 |
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