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The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients

BACKGROUND: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cuto...

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Autores principales: Sittichanbuncha, Yuwares, Sricharoen, Pungkava, Tangkulpanich, Panvilai, Sawanyawisuth, Kittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531016/
https://www.ncbi.nlm.nih.gov/pubmed/26345153
http://dx.doi.org/10.2147/TCRM.S85671
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author Sittichanbuncha, Yuwares
Sricharoen, Pungkava
Tangkulpanich, Panvilai
Sawanyawisuth, Kittisak
author_facet Sittichanbuncha, Yuwares
Sricharoen, Pungkava
Tangkulpanich, Panvilai
Sawanyawisuth, Kittisak
author_sort Sittichanbuncha, Yuwares
collection PubMed
description BACKGROUND: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cutoff points in chronic kidney disease (CKD) patients who had coronary artery occlusion. PATIENTS AND METHODS: The study was conducted at the Emergency Department, Ramathibodi Hospital, Mahidol University, Thailand. CKD patients stage 3–5 who had HS Trop T levels after 2 hours of chest pain and had coronary angiographic results were enrolled. Patients were divided into two groups: those who had significant occlusion of more than 70% of a coronary artery as the coronary artery disease (CAD) group and the non-CAD group. RESULTS: In total, 210 patients met the study criteria. There were 132 patients (62.86%) who had significant stenosis of coronary arteries by coronary angiograms. The average age (standard deviation) of all patients was 71.02 (9.49) years. HS Trop T levels were significantly higher in all CKD patients with CAD than the non-CAD group (0.4973 versus 0.0384 ng/mL). Sex and HS Trop T levels were significantly associated with CAD by multivariate logistic regression analysis. The HS Trop T level of 0.041 ng/mL gave sensitivity and specificity of 65.91% and 75.65%, respectively, for CAD. CONCLUSION: The HS Trop T level of 0.041 ng/mL provided diagnostic properties for established coronary artery occlusion in CKD patients.
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spelling pubmed-45310162015-09-04 The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients Sittichanbuncha, Yuwares Sricharoen, Pungkava Tangkulpanich, Panvilai Sawanyawisuth, Kittisak Ther Clin Risk Manag Original Research BACKGROUND: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cutoff points in chronic kidney disease (CKD) patients who had coronary artery occlusion. PATIENTS AND METHODS: The study was conducted at the Emergency Department, Ramathibodi Hospital, Mahidol University, Thailand. CKD patients stage 3–5 who had HS Trop T levels after 2 hours of chest pain and had coronary angiographic results were enrolled. Patients were divided into two groups: those who had significant occlusion of more than 70% of a coronary artery as the coronary artery disease (CAD) group and the non-CAD group. RESULTS: In total, 210 patients met the study criteria. There were 132 patients (62.86%) who had significant stenosis of coronary arteries by coronary angiograms. The average age (standard deviation) of all patients was 71.02 (9.49) years. HS Trop T levels were significantly higher in all CKD patients with CAD than the non-CAD group (0.4973 versus 0.0384 ng/mL). Sex and HS Trop T levels were significantly associated with CAD by multivariate logistic regression analysis. The HS Trop T level of 0.041 ng/mL gave sensitivity and specificity of 65.91% and 75.65%, respectively, for CAD. CONCLUSION: The HS Trop T level of 0.041 ng/mL provided diagnostic properties for established coronary artery occlusion in CKD patients. Dove Medical Press 2015-08-04 /pmc/articles/PMC4531016/ /pubmed/26345153 http://dx.doi.org/10.2147/TCRM.S85671 Text en © 2015 Sittichanbuncha et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sittichanbuncha, Yuwares
Sricharoen, Pungkava
Tangkulpanich, Panvilai
Sawanyawisuth, Kittisak
The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
title The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
title_full The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
title_fullStr The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
title_full_unstemmed The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
title_short The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
title_sort appropriate troponin t level associated with coronary occlusions in chronic kidney disease patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531016/
https://www.ncbi.nlm.nih.gov/pubmed/26345153
http://dx.doi.org/10.2147/TCRM.S85671
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