Cargando…
The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
BACKGROUND: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cuto...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531016/ https://www.ncbi.nlm.nih.gov/pubmed/26345153 http://dx.doi.org/10.2147/TCRM.S85671 |
_version_ | 1782384971243061248 |
---|---|
author | Sittichanbuncha, Yuwares Sricharoen, Pungkava Tangkulpanich, Panvilai Sawanyawisuth, Kittisak |
author_facet | Sittichanbuncha, Yuwares Sricharoen, Pungkava Tangkulpanich, Panvilai Sawanyawisuth, Kittisak |
author_sort | Sittichanbuncha, Yuwares |
collection | PubMed |
description | BACKGROUND: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cutoff points in chronic kidney disease (CKD) patients who had coronary artery occlusion. PATIENTS AND METHODS: The study was conducted at the Emergency Department, Ramathibodi Hospital, Mahidol University, Thailand. CKD patients stage 3–5 who had HS Trop T levels after 2 hours of chest pain and had coronary angiographic results were enrolled. Patients were divided into two groups: those who had significant occlusion of more than 70% of a coronary artery as the coronary artery disease (CAD) group and the non-CAD group. RESULTS: In total, 210 patients met the study criteria. There were 132 patients (62.86%) who had significant stenosis of coronary arteries by coronary angiograms. The average age (standard deviation) of all patients was 71.02 (9.49) years. HS Trop T levels were significantly higher in all CKD patients with CAD than the non-CAD group (0.4973 versus 0.0384 ng/mL). Sex and HS Trop T levels were significantly associated with CAD by multivariate logistic regression analysis. The HS Trop T level of 0.041 ng/mL gave sensitivity and specificity of 65.91% and 75.65%, respectively, for CAD. CONCLUSION: The HS Trop T level of 0.041 ng/mL provided diagnostic properties for established coronary artery occlusion in CKD patients. |
format | Online Article Text |
id | pubmed-4531016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45310162015-09-04 The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients Sittichanbuncha, Yuwares Sricharoen, Pungkava Tangkulpanich, Panvilai Sawanyawisuth, Kittisak Ther Clin Risk Manag Original Research BACKGROUND: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cutoff points in chronic kidney disease (CKD) patients who had coronary artery occlusion. PATIENTS AND METHODS: The study was conducted at the Emergency Department, Ramathibodi Hospital, Mahidol University, Thailand. CKD patients stage 3–5 who had HS Trop T levels after 2 hours of chest pain and had coronary angiographic results were enrolled. Patients were divided into two groups: those who had significant occlusion of more than 70% of a coronary artery as the coronary artery disease (CAD) group and the non-CAD group. RESULTS: In total, 210 patients met the study criteria. There were 132 patients (62.86%) who had significant stenosis of coronary arteries by coronary angiograms. The average age (standard deviation) of all patients was 71.02 (9.49) years. HS Trop T levels were significantly higher in all CKD patients with CAD than the non-CAD group (0.4973 versus 0.0384 ng/mL). Sex and HS Trop T levels were significantly associated with CAD by multivariate logistic regression analysis. The HS Trop T level of 0.041 ng/mL gave sensitivity and specificity of 65.91% and 75.65%, respectively, for CAD. CONCLUSION: The HS Trop T level of 0.041 ng/mL provided diagnostic properties for established coronary artery occlusion in CKD patients. Dove Medical Press 2015-08-04 /pmc/articles/PMC4531016/ /pubmed/26345153 http://dx.doi.org/10.2147/TCRM.S85671 Text en © 2015 Sittichanbuncha et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Sittichanbuncha, Yuwares Sricharoen, Pungkava Tangkulpanich, Panvilai Sawanyawisuth, Kittisak The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients |
title | The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients |
title_full | The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients |
title_fullStr | The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients |
title_full_unstemmed | The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients |
title_short | The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients |
title_sort | appropriate troponin t level associated with coronary occlusions in chronic kidney disease patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531016/ https://www.ncbi.nlm.nih.gov/pubmed/26345153 http://dx.doi.org/10.2147/TCRM.S85671 |
work_keys_str_mv | AT sittichanbunchayuwares theappropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT sricharoenpungkava theappropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT tangkulpanichpanvilai theappropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT sawanyawisuthkittisak theappropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT sittichanbunchayuwares appropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT sricharoenpungkava appropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT tangkulpanichpanvilai appropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients AT sawanyawisuthkittisak appropriatetroponintlevelassociatedwithcoronaryocclusionsinchronickidneydiseasepatients |