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Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients
The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV(1)] =54%...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531022/ https://www.ncbi.nlm.nih.gov/pubmed/26345641 http://dx.doi.org/10.2147/COPD.S85954 |
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author | Ferrari, Renata Caram, Laura MO Faganello, Marcia M Sanchez, Fernanda F Tanni, Suzana E Godoy, Irma |
author_facet | Ferrari, Renata Caram, Laura MO Faganello, Marcia M Sanchez, Fernanda F Tanni, Suzana E Godoy, Irma |
author_sort | Ferrari, Renata |
collection | PubMed |
description | The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV(1)] =54%±23%) were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT); midthigh cross-sectional muscle area (MTCSA) and midarm cross-sectional muscle area (MACSA) were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV(1)%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001), between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001), and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001). Plasma TNF-α was negatively associated with leg extension (−3.09 [−5.99, −0.18]; P=0.04) and triceps pulley (−1.31 [−2.35, −0.28]; P=0.01), while plasma CRP presented negative association with biceps curl (−0.06 [−0.11, −0.01]; P=0.02). Our results showed negative association between peripheral muscle mass (evaluated by CT) and muscle strength and that systemic inflammation has a negative influence in the strength of specific groups of muscles in individuals with stable COPD. This is the first study showing association between systemic inflammatory markers and strength in upper limb muscles. |
format | Online Article Text |
id | pubmed-4531022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45310222015-09-04 Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients Ferrari, Renata Caram, Laura MO Faganello, Marcia M Sanchez, Fernanda F Tanni, Suzana E Godoy, Irma Int J Chron Obstruct Pulmon Dis Original Research The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV(1)] =54%±23%) were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT); midthigh cross-sectional muscle area (MTCSA) and midarm cross-sectional muscle area (MACSA) were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV(1)%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001), between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001), and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001). Plasma TNF-α was negatively associated with leg extension (−3.09 [−5.99, −0.18]; P=0.04) and triceps pulley (−1.31 [−2.35, −0.28]; P=0.01), while plasma CRP presented negative association with biceps curl (−0.06 [−0.11, −0.01]; P=0.02). Our results showed negative association between peripheral muscle mass (evaluated by CT) and muscle strength and that systemic inflammation has a negative influence in the strength of specific groups of muscles in individuals with stable COPD. This is the first study showing association between systemic inflammatory markers and strength in upper limb muscles. Dove Medical Press 2015-08-06 /pmc/articles/PMC4531022/ /pubmed/26345641 http://dx.doi.org/10.2147/COPD.S85954 Text en © 2015 Ferrari et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ferrari, Renata Caram, Laura MO Faganello, Marcia M Sanchez, Fernanda F Tanni, Suzana E Godoy, Irma Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients |
title | Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients |
title_full | Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients |
title_fullStr | Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients |
title_full_unstemmed | Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients |
title_short | Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients |
title_sort | relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable copd patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531022/ https://www.ncbi.nlm.nih.gov/pubmed/26345641 http://dx.doi.org/10.2147/COPD.S85954 |
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