Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of rapamycin (mTOR) signaling, a conserved longevity pathway and a key regulator of protein homeostasis, yet their effects on proteome homeostasis are relat...

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Detalles Bibliográficos
Autores principales: Karunadharma, Pabalu P, Basisty, Nathan, Dai, Dao-Fu, Chiao, Ying A, Quarles, Ellen K, Hsieh, Edward J, Crispin, David, Bielas, Jason H, Ericson, Nolan G, Beyer, Richard P, MacKay, Vivian L, MacCoss, Michael J, Rabinovitch, Peter S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531069/
https://www.ncbi.nlm.nih.gov/pubmed/25807975
http://dx.doi.org/10.1111/acel.12317

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