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Implementation of a Model of Bodily Fluids Regulation

The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13–46, 1972a; Ann Biomed Eng 1:254–281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whe...

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Autores principales: Fontecave-Jallon, Julie, Thomas, S. Randall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531145/
https://www.ncbi.nlm.nih.gov/pubmed/25935135
http://dx.doi.org/10.1007/s10441-015-9250-3
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author Fontecave-Jallon, Julie
Thomas, S. Randall
author_facet Fontecave-Jallon, Julie
Thomas, S. Randall
author_sort Fontecave-Jallon, Julie
collection PubMed
description The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13–46, 1972a; Ann Biomed Eng 1:254–281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension (Montani et al. in Exp Physiol 24:41–54, 2009a; Exp Physiol 94:382–388, 2009b; Osborn et al. in Exp Physiol 94:389–396, 2009a; Exp Physiol 94:388–389, 2009b). Key to the success of this model was the fact that the authors made the computer code (in FORTRAN) freely available and eventually provided a convivial user interface for exploration of model behavior on early microcomputers (Montani et al. in Int J Bio-med Comput 24:41–54, 1989). Ikeda et al. (Ann Biomed Eng 7:135–166, 1979) developed an offshoot of the Guyton model targeting especially the regulation of body fluids and acid–base balance; their model provides extended renal and respiratory functions and would be a good basis for further extensions. In the interest of providing a simple, useable version of Ikeda et al.’s model and to facilitate further such extensions, we present a practical implementation of the model of Ikeda et al. (Ann Biomed Eng 7:135–166, 1979), using the ODE solver Berkeley Madonna. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10441-015-9250-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-45311452015-08-11 Implementation of a Model of Bodily Fluids Regulation Fontecave-Jallon, Julie Thomas, S. Randall Acta Biotheor Regular Article The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13–46, 1972a; Ann Biomed Eng 1:254–281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension (Montani et al. in Exp Physiol 24:41–54, 2009a; Exp Physiol 94:382–388, 2009b; Osborn et al. in Exp Physiol 94:389–396, 2009a; Exp Physiol 94:388–389, 2009b). Key to the success of this model was the fact that the authors made the computer code (in FORTRAN) freely available and eventually provided a convivial user interface for exploration of model behavior on early microcomputers (Montani et al. in Int J Bio-med Comput 24:41–54, 1989). Ikeda et al. (Ann Biomed Eng 7:135–166, 1979) developed an offshoot of the Guyton model targeting especially the regulation of body fluids and acid–base balance; their model provides extended renal and respiratory functions and would be a good basis for further extensions. In the interest of providing a simple, useable version of Ikeda et al.’s model and to facilitate further such extensions, we present a practical implementation of the model of Ikeda et al. (Ann Biomed Eng 7:135–166, 1979), using the ODE solver Berkeley Madonna. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10441-015-9250-3) contains supplementary material, which is available to authorized users. Springer Netherlands 2015-05-03 2015 /pmc/articles/PMC4531145/ /pubmed/25935135 http://dx.doi.org/10.1007/s10441-015-9250-3 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Regular Article
Fontecave-Jallon, Julie
Thomas, S. Randall
Implementation of a Model of Bodily Fluids Regulation
title Implementation of a Model of Bodily Fluids Regulation
title_full Implementation of a Model of Bodily Fluids Regulation
title_fullStr Implementation of a Model of Bodily Fluids Regulation
title_full_unstemmed Implementation of a Model of Bodily Fluids Regulation
title_short Implementation of a Model of Bodily Fluids Regulation
title_sort implementation of a model of bodily fluids regulation
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531145/
https://www.ncbi.nlm.nih.gov/pubmed/25935135
http://dx.doi.org/10.1007/s10441-015-9250-3
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