Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

Clinical observations indicate that activation of the TNF-α system may contribute to the development of inflammation-associated depression. Here, we tested the hypothesis that systemic upregulation of TNF-α induces neuroinflammation and behavioral changes relevant to depression. We report that a sin...

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Detalles Bibliográficos
Autores principales: Biesmans, Steven, Bouwknecht, Jan A., Ver Donck, Luc, Langlois, Xavier, Acton, Paul D., De Haes, Patrick, Davoodi, Nima, Meert, Theo F., Hellings, Niels, Nuydens, Rony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531164/
https://www.ncbi.nlm.nih.gov/pubmed/26290874
http://dx.doi.org/10.1155/2015/716920

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